Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

The effect of quercetin supplementation on clinical outcomes in COVID-19 patients: A systematic review and meta-analysis.

  • 2023-09-26
  • Food science & nutrition 11(12)
    • Somayeh Ziaei
    • Malek Alimohammadi-Kamalabadi
    • Motahareh Hasani
    • Mahsa Malekahmadi
    • Emma Persad
    • Javad Heshmati

Study Design

Type
Review
Sample size
n = 544
Population
544 patients with COVID-19
Methods
Systematic review and meta-analysis of randomized controlled trials comparing quercetin supplementation versus controls, search conducted on PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library until August 25, 2023
Coronavirus disease (COVID-19) affects both the respiratory system and the body as a whole. Natural molecules, such as flavonoid quercetin, as potential treatment methods to help patients combat COVID-19. The aim of this systematic review and meta-analysis is to give a comprehensive overview of the impact of quercetin supplementation on inflammatory factors, hospital admission, and mortality of patients with COVID-19. The search has been conducted on PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library using relevant keywords until August 25, 2023. We included randomized controlled trials (RCTs) comparing COVID-19 patients who received quercetin supplementation versus controls. We included five studies summarizing the evidence in 544 patients. Meta-analysis showed that quercetin administration significantly reduced LDH activity (standard mean difference (SMD): -0.42, 95% CI: -0.82, -0.02, I2 = 48.86%), decreased the risk of hospital admission by 70% (RR: 0.30, 95% CI: 0.14, 0.62, I2 = 00.00%), ICU admission by 73% (RR: 0.27, 95% CI: 0.09, 0.78, I2 = 20.66%), and mortality by 82% (RR: 0.18, 95% CI: 0.03, 0.98, I2 = 00.00%). No significant changes in CRP, D-dimmer, and ferritin were found between groups. Quercetin was found to significantly reduce LDH levels and decrease the risk of hospital and ICU admission and mortality in patients with COVID-19 infection.

Research Insights

Back to top