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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Reishi and Increased HDL Cholesterol Levels

Doses used in studies

mg/day: 200–11,200 (median 5,700, IQR 200–11,200) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 2 studies

Safety in these studies

renal function parametersNo significant difference
Safety analyses revealed that the intervention had no notable effects on renal function parameters
from: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomize
Overall tolerabilityReported
favorable safety and tolerability profile
from: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomize

2 of 2 papers

Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.
- 2025-02-28
- RCT · n = 110
- Nutrients 17(5)
- - Xinyi Wang
  - Xufeng Wang
  - Liang Zhao
  - Feng Zhou
- PubMed: 40077714
- DOI: 10.3390/nu17050844
6 Insights on
- Increased HDL Cholesterol Levels
- High evidence
- Large Human Trial
- Rigorous Journal
- Clinical
After 12 weeks of intervention, the intervention group exhibited... significantly higher levels of high-density lipoprotein cholesterol (HDL-C), compared to the placebo group
Effect
Beneficial
Effect size
Small
Significant
Yes
The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.
- 2025-06-12
- Review · n = 971
- Food science & nutrition 13(6)
- - Ali Jafari
  - Helia Mardani
  - Zahra Mirzaei Fashtali
  - Bahareh Arghavan
- PubMed: 40510787
- DOI: 10.1002/fsn3.70423
17 Insights on
- Increased HDL Cholesterol Levels
- High evidence
- Clinical
No significant effects were observed on ... lipid profile ...
Effect
Neutral
Effect size
Small
Significant
No
Dose
200-11,200 mg/day