Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

2025-02-28
Nutrients 17(5)
- Xinyi Wang
- Xufeng Wang
- Liang Zhao
- Feng Zhou

PubMed: 40077714
DOI: 10.3390/nu17050844

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 110
Population: 110 participants with dyslipidemia
Methods: randomized, double-blind, placebo-controlled trial, participants randomly assigned to intervention or placebo group
Blinding: Double-blind
Duration: 12 weeks
Funding: Unclear

Large Human Trial
Rigorous Journal

Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. This study aimed to systematically evaluate the efficacy and safety of GLSO extract in individuals with dyslipidemia. Methods: In a randomized, double-blind, placebo-controlled trial, 110 participants were enrolled and randomly assigned to either the intervention group or the placebo group. A chi-square test of baseline characteristics confirmed no significant differences in age or sex distribution between the two groups. Results: After 12 weeks of intervention, the intervention group exhibited significantly lower levels of total cholesterol (CHO), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), alongside significantly higher levels of high-density lipoprotein cholesterol (HDL-C), compared to the placebo group, with all differences reaching statistical significance. Furthermore, the relative percentage changes in lipid parameters also demonstrated significant intergroup differences. Safety analyses revealed that the intervention had no notable effects on renal function parameters, whereas hepatic function parameters showed statistically significant improvement in the intervention group. Conclusions: This study demonstrated that GLSO extract effectively improved lipid profiles and liver function, with a favorable safety and tolerability profile. These findings strongly support the potential clinical application of GLSO extract in the management of dyslipidemia.

Research Insights

Reishi→Improved Liver Function
Safety analyses revealed that... hepatic function parameters showed statistically significant improvement in the intervention group
Effect
Beneficial
Effect size
Small
Reishi→Improved Renal Function
Safety analyses revealed that the intervention had no notable effects on renal function parameters
Effect
Neutral
Effect size
Small
Reishi→Increased HDL Cholesterol Levels
After 12 weeks of intervention, the intervention group exhibited... significantly higher levels of high-density lipoprotein cholesterol (HDL-C), compared to the placebo group
Effect
Beneficial
Effect size
Small
Reishi→Reduced Blood Cholesterol
After 12 weeks of intervention, the intervention group exhibited significantly lower levels of total cholesterol (CHO)... compared to the placebo group
Effect
Beneficial
Effect size
Small
Reishi→Reduced Low-Density Lipoprotein Level
After 12 weeks of intervention, the intervention group exhibited significantly lower levels of... low-density lipoprotein cholesterol (LDL-C)... compared to the placebo group
Effect
Beneficial
Effect size
Small
Reishi→Reduced Triglyceride Levels
After 12 weeks of intervention, the intervention group exhibited significantly lower levels of... triglycerides (TG)... compared to the placebo group
Effect
Beneficial
Effect size
Small

Adverse Events Reported

Reishi→renal function parameters
Safety analyses revealed that the intervention had no notable effects on renal function parameters
Finding
No significant difference
Significant
No
Reishi→Overall tolerability
favorable safety and tolerability profile
Finding
Reported