Reishi and Reduced Triglyceride Levels

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, 1 reported beneficial small effects on triglycerides, while 2 found no significant effect. The beneficial study was an 84-day RCT in 110 participants with dyslipidemia using reishi spore oil. The median study duration was 63 days, but effects were observed at 12 weeks.

Studied populations: individuals with dyslipidemia

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Only 1 of 3 studies reached statistical significance, so the effect may be smaller or inconsistent.

Generated Jul 10, 2026

Doses used in studies

g/day: 6 (median 6, IQR 6–6) — 1 study
mg/day: 200–11,200 (median 5,700, IQR 200–11,200) — 1 study

Time to effect

Median: 9 weeks · IQR 7.5 weeks–10.5 weeks · Range 6 weeks–2.8 months — Reported in 2 of 3 studies

Safety in these studies

renal function parametersNo significant difference
Safety analyses revealed that the intervention had no notable effects on renal function parameters
from: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomize
Overall tolerabilityReported
favorable safety and tolerability profile
from: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomize

3 of 3 papers

Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.
- 2025-02-28
- RCT · n = 110
- Nutrients 17(5)
- - Xinyi Wang
  - Xufeng Wang
  - Liang Zhao
  - Feng Zhou
- PubMed: 40077714
- DOI: 10.3390/nu17050844
6 Insights on
- Reduced Triglyceride Levels
- High evidence
- Large Human Trial
- Rigorous Journal
- Clinical
After 12 weeks of intervention, the intervention group exhibited significantly lower levels of... triglycerides (TG)... compared to the placebo group
Effect
Beneficial
Effect size
Small
Significant
Yes
Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia.
- 2021-02-01
- RCT
- Nutricion hospitalaria 38(1)
- - Francesco Pazzi
  - José Carmelo Adsuar
  - Francisco Javier Domínguez-Muñoz
  - Miguel Ángel García-Gordillo
  - Narci Gusi
  - Daniel Collado-Mateo
- PubMed: 33319566
- DOI: 10.20960/nh.03190
8 Insights on
- Reduced Triglyceride Levels
- High evidence
- Clinical
our results did not show any statistically significant differences in any of the outcome measures
Effect
Neutral
Effect size
Small
Significant
No
Dose
6 g/day
The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.
- 2025-06-12
- Review · n = 971
- Food science & nutrition 13(6)
- - Ali Jafari
  - Helia Mardani
  - Zahra Mirzaei Fashtali
  - Bahareh Arghavan
- PubMed: 40510787
- DOI: 10.1002/fsn3.70423
17 Insights on
- Reduced Triglyceride Levels
- High evidence
- Clinical
No significant effects were observed on ... lipid profile ...
Effect
Neutral
Effect size
Small
Significant
No
Dose
200-11,200 mg/day

Reishi and Reduced Triglyceride Levels

Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia.

The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.