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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Reishi and Reduced Blood Cholesterol

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, 1 reported a beneficial small effect on reducing total cholesterol in participants with dyslipidemia, while 2 found neutral effects with no significant changes in lipid profiles. The median study duration was 63 days (8-12 weeks), with the single beneficial study lasting 12 weeks. The most-studied populations were clinical (dyslipidemia, fibromyalgia), and the evidence does not converge on a specific effective dose range.

  • Studied populations: people with dyslipidemia

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Only 1 of 3 studies reached statistical significance, and the effect was small; the majority of findings were neutral, suggesting that any cholesterol-lowering benefit may not be robust or consistent.

Generated Jul 10, 2026
Doses used in studies
  • g/day: 6 (median 6, IQR 6–6) — 1 study
  • mg/day: 200–11,200 (median 5,700, IQR 200–11,200) — 1 study
Time to effect
Median: 9 weeks · IQR 7.5 weeks–10.5 weeks · Range 6 weeks–2.8 months — Reported in 2 of 3 studies
Safety in these studies
3 of 3 papers
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