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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Reishi and Reduced Blood Cholesterol

Doses used in studies

mg/day: 200–11,200 (median 5,700, IQR 200–11,200) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 2 studies

Safety in these studies

renal function parametersNo significant difference
Safety analyses revealed that the intervention had no notable effects on renal function parameters
from: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomize
Overall tolerabilityReported
favorable safety and tolerability profile
from: Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomize

2 of 2 papers

Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.
- 2025-02-28
- RCT · n = 110
- Nutrients 17(5)
- - Xinyi Wang
  - Xufeng Wang
  - Liang Zhao
  - Feng Zhou
- PubMed: 40077714
- DOI: 10.3390/nu17050844
6 Insights on
- Reduced Blood Cholesterol
- High evidence
- Large Human Trial
- Rigorous Journal
- Clinical
After 12 weeks of intervention, the intervention group exhibited significantly lower levels of total cholesterol (CHO)... compared to the placebo group
Effect
Beneficial
Effect size
Small
Significant
Yes
The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.
- 2025-06-12
- Review · n = 971
- Food science & nutrition 13(6)
- - Ali Jafari
  - Helia Mardani
  - Zahra Mirzaei Fashtali
  - Bahareh Arghavan
- PubMed: 40510787
- DOI: 10.1002/fsn3.70423
17 Insights on
- Reduced Blood Cholesterol
- High evidence
- Clinical
No significant effects were observed on ... lipid profile ...
Effect
Neutral
Effect size
Small
Significant
No
Dose
200-11,200 mg/day