Resveratrol and Reduced Body Weight

Across 3 studies, 2 reported beneficial effects of resveratrol on reducing body weight, with effects ranging from small to moderate. The strongest evidence comes from a large systematic review in adults with MASLD (sample size 4572) showing a moderate beneficial effect, while a meta-analysis in individuals with type 2 diabetes found a statistically significant but small decrease in body weight (WMD: -0.44 kg). However, a meta-analysis in people with overweight and obesity found a neutral effect that did not reach statistical significance. Study durations and doses were not consistently reported across the included reviews.

• Studied populations: adults with MASLD (metabolic dysfunction-associated steatotic liver disease), individuals with type 2 diabetes

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The beneficial effect was not consistent across populations: a meta-analysis in overweight and obese individuals found no significant effect on body weight, suggesting benefit may be specific to certain clinical populations. The clinical significance of the small effect size in the T2D meta-analysis (mean reduction of less than half a kilogram) is uncertain.