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The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials.

  • 2025-12-27
  • International journal of obesity (2005) 50(3)
    • Azin Setayesh
    • Pishva Arzhang
    • Mohammadreza Moradi Baniasadi
    • Maryam Lahouti
    • Leila Azadbakht

Study Design

Type
Meta-Analysis
Sample size
n = 1,005
Population
individuals with overweight and obesity
Methods
systematic review and meta-analysis of randomized controlled trials; searched Scopus, Web of Science, and PubMed up to September 2025

Background

The effects of resveratrol supplementation on anthropometric indices, adiponectin, and leptin levels remain inconclusive in individuals with overweight and obesity.

Method

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effects of resveratrol supplementation on anthropometric indices, adiponectin, and leptin levels. We searched electronic databases, including Scopus, Web of Science, and PubMed, up to September 2025, to identify eligible RCTs.

Results

A total of 23 RCTs, involving 1005 participants, met the inclusion criteria for the meta-analysis. Resveratrol supplementation did not significantly affect body weight (WMD: -1.42 kg; 95% CI: -3.19, 0.35; P = 0.117), body mass index (BMI) (WMD: -0.47 kg/m²; 95% CI: -0.96, 0.01; P = 0.055), fat mass (FM) (WMD: 0.47 kg; 95% CI: -1.75, 2.69; P = 0.679), body fat percentage (BFP) (WMD: -0.88%; 95% CI: -1.91, 0.15; P = 0.094), fat-free mass (FFM) (WMD: 1.42 kg; 95% CI: -1.04, 3.89; P = 0.257), waist-hip ratio (WHR) (WMD: -0.00; 95% CI: -0.01, 0.00; P = 0.436), adiponectin (WMD: 1.84 µg/mL; 95% CI: -2.25, 5.95; P = 0.378), or leptin (WMD: 1.87 ng/mL; 95% CI: -3.84, 7.60; P = 0.521). However, resveratrol supplementation significantly reduced waist circumference (WC) (WMD: -1.93 cm; 95% CI: -3.10, -0.76; P = 0.001). Subgroup analyses revealed significant reductions in body weight and BMI with doses <1000 mg/day, longer interventions (≥12 weeks), and in females. Additionally, FFM increased significantly among participants aged <50 years, and leptin levels were significantly elevated in both sexes.

Conclusion

This meta-analysis showed that resveratrol supplementation did not significantly impact most anthropometric measures and serum leptin and adiponectin in individuals with overweight and obesity. However, it led to a significant reduction in waist circumference. The PROSPERO registration number: is CRD42024497932.

Research Insights

  • Resveratrol→Increased Adiponectin Levels

    Resveratrol supplementation did not significantly affect adiponectin (WMD: 1.84 µg/mL; 95% CI: -2.25, 5.95; P = 0.378)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Increased Fat-Free Mass

    Resveratrol supplementation did not significantly affect fat-free mass (FFM) (WMD: 1.42 kg; 95% CI: -1.04, 3.89; P = 0.257)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Increased Leptin Level

    Resveratrol supplementation did not significantly affect leptin (WMD: 1.87 ng/mL; 95% CI: -3.84, 7.60; P = 0.521)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Body Fat Mass

    Resveratrol supplementation did not significantly affect fat mass (FM) (WMD: 0.47 kg; 95% CI: -1.75, 2.69; P = 0.679)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Body Fat Percentage

    Resveratrol supplementation did not significantly affect body fat percentage (BFP) (WMD: -0.88%; 95% CI: -1.91, 0.15; P = 0.094)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Body Mass Index

    Resveratrol supplementation did not significantly affect body mass index (BMI) (WMD: -0.47 kg/m²; 95% CI: -0.96, 0.01; P = 0.055)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Body Weight

    Resveratrol supplementation did not significantly affect body weight (WMD: -1.42 kg; 95% CI: -3.19, 0.35; P = 0.117)

    Effect
    Neutral
    Effect size
    Small
  • Resveratrol→Reduced Waist Circumference

    However, resveratrol supplementation significantly reduced waist circumference (WC) (WMD: -1.93 cm; 95% CI: -3.10, -0.76; P = 0.001)

    Effect
    Beneficial
    Effect size
    Small
  • Resveratrol→Reduced Waist-to-Height Ratio

    Resveratrol supplementation did not significantly affect waist-hip ratio (WHR) (WMD: -0.00; 95% CI: -0.01, 0.00; P = 0.436)

    Effect
    Neutral
    Effect size
    Small
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