St. John's Wort and Reduced Menopausal Symptoms

• Hypericum perforatum L.: A legacy of herbal medicine in light of modern scientific evidence.

  • 2026-12
  • Review
  • Journal of ethnopharmacology 371
  • • Xuege Pan
    • Weifeng Yin
    • Fulin Zhou
    • Maoli Bai
    • Jun He
    • Kang Ding
    • Jiekun Xu
    • Weiku Zhang

  • PubMed: 42302936
  • DOI: 10.1016/j.jep.2026.122066

  3 Insights on

  • Reduced Menopausal Symptoms

  • Low evidence

  The strongest clinical evidence supports its use in mild-to-moderate depression and menopausal symptoms, with efficacy comparable to SSRIs and superiority over placebo.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes