Thistle and Improved Insulin Sensitivity

• Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials.

  • 2025-02
  • Meta-Analysis · n = 673
  • Diabetes research and clinical practice 220
  • • Shao Yin
    • Fengya Zhu
    • Ying Liu
    • Qiu Chen

  • PubMed: 39855603
  • DOI: 10.1016/j.diabres.2025.112008

  3 Insights on

  • Improved Insulin Sensitivity

  • High evidence

  QUICKI did not show significant changes in any group. Only one study reported changes in QUICKI.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

• Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.

  • 2025-05-29
  • Systematic Review · n = 337
  • Phytotherapy research : PTR 39(12)
  • • Runyu Miao
    • Boxun Zhang
    • Danni Zhou
    • Mengjiao Kang
    • Jiaxing Tian
    • Linhua Zhao
    • Xiaolin Tong

  • PubMed: 40439602
  • DOI: 10.1002/ptr.8431

  12 Insights on

  • Improved Insulin Sensitivity

  • High evidence
  • Clinical

  silymarin significantly improved fasting plasma glucose (FPG), HOMA-IR, and hemoglobin A1c (HbA1c) (P < 0.05)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes