Thistle and Reduced HOMA-IR

• Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials.

  • 2025-02
  • Meta-Analysis · n = 673
  • Diabetes research and clinical practice 220
  • • Shao Yin
    • Fengya Zhu
    • Ying Liu
    • Qiu Chen

  • PubMed: 39855603
  • DOI: 10.1016/j.diabres.2025.112008

  3 Insights on

  • Reduced HOMA-IR

  • High evidence

  Meta-analysis showed that Silybum marianum significantly improved HOMA-IR (WMD = -2.29, 95% CI: -4.55 to -0.03, p = 0.047)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes