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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Selenium and Reduced Total Cholesterol Levels

Doses used in studies

mcg/day: 200 (median 200, IQR 200–200) — 1 study
µg/day: 100–200 (median 150, IQR 100–200) — 1 study

Time to effect

Median: 7.3 weeks · IQR 6.6 weeks–7.9 weeks · Range 6 weeks–8.6 weeks — Reported in 2 of 2 studies

2 of 2 papers

Selenium supplementation for management of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of randomized controlled trials.
- 2025-10-10
- Meta-Analysis · n = 230
- BMC endocrine disorders 25(1)
- - Juan Sun
  - Lei Liu
  - Juxiang Shen
  - Juan Du
- PubMed: 41073938
- DOI: 10.1186/s12902-025-02045-5
7 Insights on
- Reduced Total Cholesterol Levels
- High evidence
- Clinical
there was no obvious differences in improving total cholesterol, triglycerides, low density lipoprotein cholesterol and high density lipoprotein cholesterol
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 µg/day to 200 µg/day
Effect of Selenomethionine- Enriched Yeast on Hypothyroidism Patients.
- 2025-02-01
- RCT · n = 40
- Archives of Razi Institute 80(1)
- - A Hajyasini
  - A Dehnad
  - A Farzi
  - M Mobasseri
  - A Ostadrahimi
  - B Kafili
- PubMed: 40951555
- DOI: 10.32592/ari.2025.80.1.257
7 Insights on
- Reduced Total Cholesterol Levels
- High evidence
- Clinical
However, catalase enzyme, lipid profile components, and liver enzymes in the intervention group remained largely unchanged compared to the pre-intervention and control groups (P>0.05).
Effect
Neutral
Effect size
Small
Significant
No
Dose
200 µg/day for 60 days