Effect of Selenomethionine- Enriched Yeast on Hypothyroidism Patients.

2025-02-01
Archives of Razi Institute 80(1)
- A Hajyasini
- A Dehnad
- A Farzi
- M Mobasseri
- A Ostadrahimi
- B Kafili

PubMed: 40951555
DOI: 10.32592/ari.2025.80.1.257

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 40
Population: 40 patients with Hashimoto's thyroiditis
Methods: Double-blind, randomized clinical trial, enrolling 40 patients in two equal control (placebo) and intervention (Selenium) groups. Participants received 200 micrograms of Selenium over 60 days, with blood samples collected before and after the intervention.
Blinding: Double-blind
Duration: 60 days
Funding: Unclear

Selenium (Se) is a trace mineral that plays a critical role in public health. It is a vital component of numerous enzymes and proteins called selenoproteins, thus affecting a wide range of biological activities. Hashimoto's disease is the most common cause of hypothyroidism. In addition to being a critical micronutrient for thyroid health, selenium has a direct association with liver health. The objective of this study is to examine the impact of Selenium on lipid factors, thyroid factors (anti-TPO and TSH), and liver enzymes. A double-blind, randomized clinical trial was conducted, enrolling 40 patients with Hashimoto's thyroiditis in two equal control (placebo) and intervention (Selenium) groups. Participants received 200 micrograms of Selenium over 60 days, with blood samples collected before and after the intervention. The spectrophotometric method was employed to measure total blood catalase, anti-TPO, TSH, malondialdehyde, serum lipid profile, and liver factors. The results were then subjected to statistical analysis. The study revealed a significant decrease in plasma MDA levels in response to selenium consumption. Additionally, a notable increase in hemoglobin levels was observed in the experimental group following the intervention, reaching a statistical significance of P<0.05. However, catalase enzyme, lipid profile components, and liver enzymes in the intervention group remained largely unchanged compared to the pre-intervention and control groups (P>0.05).TSH and anti-TPO levels exhibited a relative decrease in the intervention group (P>0.05). The findings of this study suggest a potential association between selenium consumption and improved serum lipid factors, liver enzymes, anti-thyroid peroxidase antibody, MDA, and HGB levels in individuals diagnosed with Hashimoto's thyroiditis.

Research Insights

Selenium→Increased Hemoglobin Levels
Additionally, a notable increase in hemoglobin levels was observed in the experimental group following the intervention, reaching a statistical significance of P<0.05.
Effect
Beneficial
Effect size
Small
Dose
200 µg/day for 60 days
Selenium→Reduced Anti-Thyroid Peroxidase Antibody Level
TSH and anti-TPO levels exhibited a relative decrease in the intervention group (P>0.05).
Effect
Neutral
Effect size
Small
Dose
200 µg/day for 60 days
Selenium→Reduced Catalase Activity
However, catalase enzyme, lipid profile components, and liver enzymes in the intervention group remained largely unchanged compared to the pre-intervention and control groups (P>0.05).
Effect
Neutral
Effect size
Small
Dose
200 µg/day for 60 days
Selenium→Reduced Liver Enzyme Levels
However, catalase enzyme, lipid profile components, and liver enzymes in the intervention group remained largely unchanged compared to the pre-intervention and control groups (P>0.05).
Effect
Neutral
Effect size
Small
Dose
200 µg/day for 60 days
Selenium→Reduced Malondialdehyde Level
The study revealed a significant decrease in plasma MDA levels in response to selenium consumption.
Effect
Beneficial
Effect size
Small
Dose
200 µg/day for 60 days
Selenium→Reduced Thyroid Stimulating Hormone Level
TSH and anti-TPO levels exhibited a relative decrease in the intervention group (P>0.05).
Effect
Neutral
Effect size
Small
Dose
200 µg/day for 60 days
Selenium→Reduced Total Cholesterol Levels
However, catalase enzyme, lipid profile components, and liver enzymes in the intervention group remained largely unchanged compared to the pre-intervention and control groups (P>0.05).
Effect
Neutral
Effect size
Small
Dose
200 µg/day for 60 days