Across 3 studies, all reported beneficial effects of Bifidobacterium animalis subsp. lactis BB-12 on gut microbiota composition, with effect sizes ranging from small to moderate. One study in mice with acute pancreatitis found a statistically significant increase in beneficial Ligilactobacillus and decrease in potentially harmful Bilophila. The evidence base is too small to determine a predominant dose range or population effect.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Only 1 of the 3 studies reported a statistically significant finding, and that was in an animal model (mice with acute pancreatitis), limiting generalizability to humans. Two of the three studies did not report sample sizes or significance, and one is a review article, which does not provide original data.
probiotics offer a simpler alternative to reinforce epithelial barrier function, restore cellular homeostasis, mitigate allergy symptoms
This was achieved through a significant rise in short-chain fatty acid (SCFA)-producing bacteria ... a rise in fecal SCFAs, and a reduction in harmful bacteria such as Escherichia.
both synbiotic treatments reduced Klebsiella spp., a potentially pathogenic genus
BB-12 treatment significantly increased the relative abundance of Ligilactobacillus and decreased that of Bilophila in the gut microbiota of mice with AP.
BB-12 conferred protection on the gut microbiota composition of the rats by increasing the abundance of Prevotella and decreasing the abundance of Clostridium, Blautia, and Bacteroides in 0-3 weeks... after a long-term intervention, BB-12 ameliorates obesity by enriching beneficial bacteria in the gut.