Bifidobacterium animalis subsp. lactis BB-12 and Improved Gut Microbiota Composition

• Bioengineering Interventions to Enhance the Capacity of the Gut Microbiota in Controlling Food Allergies.

  • 2026-03-07
  • Review
  • Life (Basel, Switzerland) 16(3)
  • • Manish Kumar
    • Shivani Nalla
    • Jatindra N Tripathy
    • Akhilesh Kumar Shakya

  • PubMed: 41900952
  • DOI: 10.3390/life16030433

  6 Insights on

  • Improved Gut Microbiota Composition

  • Low evidence

  probiotics offer a simpler alternative to reinforce epithelial barrier function, restore cellular homeostasis, mitigate allergy symptoms

  Effect

  Beneficial

  Effect size

  Small

• A Synbiotic of Bifidobacterium animalis subsp. lactis BB-12 and 2'-FL Alleviate Infant Diarrhea and Anxiety-like Behaviors via Gut Microbiota Modulation in an EPEC O127 Infection Model.

  • 2025-09-29
  • Nutrients 17(19)
  • • Zhuo Liu
    • Wenxiu Wang
    • Ning Li
    • Jinkuan Chen
    • Qianxu Wang
    • Mengzhen Jia
    • Xiaorui Wang
    • Bo Zhang
    • Nan Sheng
    • Zhigang Liu

  • PubMed: 41097176
  • DOI: 10.3390/nu17193099

  11 Insights on

  • Improved Gut Microbiota Composition

  • Low evidence
  • Rigorous Journal
  • Animal Study

  This was achieved through a significant rise in short-chain fatty acid (SCFA)-producing bacteria ... a rise in fecal SCFAs, and a reduction in harmful bacteria such as Escherichia.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Polydextrose-driven gut microbiota modulation from synbiotic yogurt intake simulated in the in vitro dynamic multivessel colonic xGIbiomics system.

  • 2025-09-04
  • Frontiers in nutrition 12
  • • Rita de Cassia Pessotti
    • Mateus Salgaço
    • Laira Lorraine Agostinho
    • Miller Nunes de Freitas
    • Cristina Stewart Bittencourt Bogsan
    • Cristiano Ruch Werneck Guimaraes
    • Katia Sivieri

  • PubMed: 40977968
  • DOI: 10.3389/fnut.2025.1654738

  4 Insights on

  • Improved Gut Microbiota Composition

  • Low evidence

  both synbiotic treatments reduced Klebsiella spp., a potentially pathogenic genus

  Effect

  Beneficial

  Effect size

  Moderate

• Role of Bifidobacterium animalis subsp. lactis BB-12 in mice with acute pancreatitis.

  • 2025-04-05
  • AMB Express 15(1)
  • • Bingbing Du
    • Ren Yan
    • Xiaoxiang Hu
    • Jing Lou
    • Yixin Zhu
    • Yini Shao
    • Huiyong Jiang
    • Yingying Hao
    • Longxian Lv

  • PubMed: 40186645
  • DOI: 10.1186/s13568-025-01867-9

  5 Insights on

  • Improved Gut Microbiota Composition

  • Low evidence

  BB-12 treatment significantly increased the relative abundance of Ligilactobacillus and decreased that of Bilophila in the gut microbiota of mice with AP.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Bifidobacterium animalis subsp. lactis BB-12 Has Effect Against Obesity by Regulating Gut Microbiota in Two Phases in Human Microbiota-Associated Rats

  • 2022-01-10
  • Clinical Trial
  • Frontiers in Nutrition 8
  • • Kemin Mao
    • Jie Gao
    • Xianghong Wang
    • Xiyu Li
    • S. Geng
    • Tuo Zhang
    • F. A. Sadiq
    • Yaxin Sang

  • PubMed: 35083265
  • DOI: 10.3389/fnut.2021.811619

  13 Insights on

  • Improved Gut Microbiota Composition

  • Low evidence
  • Animal Study

  BB-12 conferred protection on the gut microbiota composition of the rats by increasing the abundance of Prevotella and decreasing the abundance of Clostridium, Blautia, and Bacteroides in 0-3 weeks... after a long-term intervention, BB-12 ameliorates obesity by enriching beneficial bacteria in the gut.

  Effect

  Beneficial

  Effect size

  Moderate