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Abstract

Bifidobacterium animalis subsp. lactis BB-12 (BB-12) is an extensively studied probiotics species, which has been reported to improve the human gut microbiota. This study aimed to confirm the effects of BB-12 on high-fat diet (HFD)-induced gut microbiota disorders. The probiotic BB-12 was consumed by human microbiota-associated rats and changes in gut microbiota were compared using next generation sequencing of the fecal samples collected from the normal chow group, the HFD group, and the BB-12-supplemented group. The enterotypes switched from Prevotella dominant to Akkermansia dominant as a result of switching diet from normal chow to HFD. BB-12 conferred protection on the gut microbiota composition of the rats by increasing the abundance of Prevotella and decreasing the abundance of Clostridium, Blautia, and Bacteroides in 0-3 weeks. In addition, Prevotella-dominant enterotype was maintained, which provides improve obesity effects. A decrease in body weight and the Firmicutes/Bacteroidetes ratio were also observed at week 3. While in 4-8 weeks, the enrichment of short-chain fatty acids-producing bacteria such as Eubacterium and Parabacteroides and probiotics such as Bifidobacterium was observed. The results revealed that BB-12 against obesity by regulating gut microbiota in two phases. After a short-term intervention, BB-12 supplementation suppressed the transition from the healthy to obesity state by protecting Prevotella-dominant enterotype, whereas after a long-term intervention, BB-12 ameliorates obesity by enriching beneficial bacteria in the gut.

Keywords: Bifidobacterium animalis subsp. lactis BB-12; Prevotella; enterotypes; gut microbiota; obesity.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalisImproved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium animalisIncreased Beneficial Gut BacteriaBeneficial
Moderate
Bifidobacterium animalisMaintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium animalisReduced Body WeightBeneficial
Moderate
Bifidobacterium animalisReduced ObesityBeneficial
Moderate
Bifidobacterium animalis subsp. lactisIncreased Beneficial Gut BacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Increased Protective Fecal Bifidobacterial DiversityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Body WeightBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced ObesityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Regulated Microbiota CompositionBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Increased Protective Fecal Bifidobacterial DiversityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Maintained Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Reduced Body WeightBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Reduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BB-12Suppressed Transition to ObesityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Improved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium animalis subsp. lactis BLC1Increased Protective Fecal Bifidobacterial DiversityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium animalis subsp. lactis BLC1Reduced Body WeightBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Protective Fecal Bifidobacterial DiversityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium animalis subsp. lactis BS-01Optimized Gut Microbiota CompositionBeneficial
Large
Bifidobacterium animalis subsp. lactis BS-01Reduced Body WeightBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Improved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Body WeightBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Improved Obesity MetricsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Beneficial Gut BacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Maintained Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Increased Beneficial Gut BacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium animalis subsp. lactis VK2Reduced Body WeightBeneficial
Moderate
Bifidobacterium bifidum BB-06Increased Beneficial Gut BacteriaBeneficial
Moderate
Bifidobacterium bifidum BB-06Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium bifidum BB-06Reduced Body WeightBeneficial
Moderate
Bifidobacterium bifidum BB-06Reduced Gut Microbiota DisorderBeneficial
Moderate
Bifidobacterium bifidum BB-06Reduced ObesityBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Improved Abundance of Beneficial BacteriaBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02Prevention of Obesity TransitionBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02Reduced Body WeightBeneficial
Moderate
Bifidobacterium lactisImproved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium lactisIncreased Beneficial Gut BacteriaBeneficial
Moderate
Bifidobacterium lactisReduced Firmicutes/Bacteroidetes RatioBeneficial
Moderate
Bifidobacterium lactisReduced ObesityBeneficial
Moderate
Bifidobacterium lactis Bb-02Increased Protective Fecal Bifidobacterial DiversityBeneficial
Moderate
Bifidobacterium lactis Bb-02Maintained Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium lactis Bb-02Reduced Body WeightBeneficial
Moderate
Bifidobacterium lactis BB-12Improved Gut Microbiome CompositionBeneficial
Large
Bifidobacterium lactis BB-12Increased Protective Fecal Bifidobacterial DiversityBeneficial
Moderate
Bifidobacterium lactis BB-12Reduced Body WeightBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Altered Gut Microbiota CompositionBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium lactis HDS Bb-02Reduced Body WeightBeneficial
Moderate
Bifidobacterium lactis UABla-12Increased Production of Short-Chain Fatty Acids by Gut BacteriaBeneficial
Large
Bifidobacterium lactis UABla-12Maintained Prevotella-Dominant Gut MicrobiotaBeneficial
Large
Bifidobacterium lactis UABla-12Optimized Gut Microbiota CompositionBeneficial
Large
Bifidobacterium lactis UABla-12Reduced Body WeightBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced ObesityBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Risk of ObesityBeneficial
Moderate

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