Bifidobacterium animalis subsp. lactis BB-12 and Improved Immune Function

Research synthesisVery low evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 review studies, all 4 reported beneficial effects of Bifidobacterium animalis subsp. lactis BB-12 on immune function, with effect sizes ranging from small to large (predominantly small to moderate). The most robust evidence comes from one high-quality review citing increased resistance to common respiratory infections. No consistent dose range was reported, and study durations were not specified.

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. All included studies are reviews, not original clinical trials, and none reported statistical significance or provided extractable dose, duration, or sample size data. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated Jun 11, 2026

4 of 4 papers

The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®
- 2014-03-28
- Review
- Microorganisms 2(2)
- - Mikkel Jungersen
  - A. Wind
  - E. Johansen
  - J. Christensen
  - Birgitte Stuer-Lauridsen
  - D. Eskesen
- PubMed: 27682233
- DOI: 10.3390/microorganisms2020092
15 Insights on
- Improved Immune Function
- High evidence
- Highly Cited
- Rigorous Journal
In terms of immune function, clinical studies have shown that BB-12(®) increases the body's resistance to common respiratory infections as well as reduces the incidence of acute respiratory tract infections.
Effect
Beneficial
Effect size
Large
Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review.
- 2026-02-19
- Review
- Frontiers in microbiology 17
- - Carlos Patricio Acosta Rodríguez Bueno
  - Ailim Carias Domínguez
  - Denis Guyonnet
  - Etienne Pouteau
- PubMed: 41800422
- DOI: 10.3389/fmicb.2026.1773473
8 Insights on
- Improved Immune Function
- Low evidence
Bifidobacteria-dominance in infancy is considered protective as they not only display both anti-inflammatory and immunomodulatory effects
Effect
Beneficial
Effect size
Small
Probiotics: A multifaceted approach to health promotion-from disease prevention to food enrichment and delivery systems.
- 2025-10-13
- Review
- AIMS microbiology 11(3)
- - Srirengaraj Vijayaram
  - Vivekanandan K E
  - Sabariswaran Kandasamy
  - Hary Razafindralambo
  - Einar Ringø
  - Yun-Zhang Sun
  - Gayathri Kaliyannan
- PubMed: 41078550
- DOI: 10.3934/microbiol.2025026
10 Insights on
- Improved Immune Function
- Low evidence
BB-12 has been associated with immune-modulating effects, including enhanced immune responses.
Effect
Beneficial
Effect size
Small
Probiotic applications of bifidobacteria in poultry: administration methods and microencapsulation techniques.
- 2024-08-22
- Review
- Microbiome research reports 4(3)
- - Eloy Argañaraz-Martínez
  - María Cristina Apella
  - Adriana Perez Chaia
  - Jaime Daniel Babot
- PubMed: 41133100
- DOI: 10.20517/mrr.2025.64
4 Insights on
- Improved Immune Function
- Low evidence
regulating immune responses through cytokine balance and epithelial barrier reinforcement.
Effect
Beneficial
Effect size
Moderate

Bifidobacterium animalis subsp. lactis BB-12 and Improved Immune Function

The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®

Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review.

Probiotics: A multifaceted approach to health promotion-from disease prevention to food enrichment and delivery systems.

Probiotic applications of bifidobacteria in poultry: administration methods and microencapsulation techniques.