Bifidobacterium animalis subsp. lactis BB-12 and Improved Immune Function

• The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®

  • 2014-03-28
  • Review
  • Microorganisms 2(2)
  • • Mikkel Jungersen
    • A. Wind
    • E. Johansen
    • J. Christensen
    • Birgitte Stuer-Lauridsen
    • D. Eskesen

  • PubMed: 27682233
  • DOI: 10.3390/microorganisms2020092

  14 Insights on

  • Improved Immune Function

  • High evidence
  • Highly Cited
  • Rigorous Journal

  In terms of immune function, clinical studies have shown that BB-12(®) increases the body's resistance to common respiratory infections as well as reduces the incidence of acute respiratory tract infections.

  Effect

  Beneficial

  Effect size

  Large

• Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review.

  • 2026-02-19
  • Review
  • Frontiers in microbiology 17
  • • Carlos Patricio Acosta Rodríguez Bueno
    • Ailim Carias Domínguez
    • Denis Guyonnet
    • Etienne Pouteau

  • PubMed: 41800422
  • DOI: 10.3389/fmicb.2026.1773473

  8 Insights on

  • Improved Immune Function

  • Low evidence

  Bifidobacteria-dominance in infancy is considered protective as they not only display both anti-inflammatory and immunomodulatory effects

  Effect

  Beneficial

  Effect size

  Small

• Probiotics: A multifaceted approach to health promotion-from disease prevention to food enrichment and delivery systems.

  • 2025-10-13
  • Review
  • AIMS microbiology 11(3)
  • • Srirengaraj Vijayaram
    • Vivekanandan K E
    • Sabariswaran Kandasamy
    • Hary Razafindralambo
    • Einar Ringø
    • Yun-Zhang Sun
    • Gayathri Kaliyannan

  • PubMed: 41078550
  • DOI: 10.3934/microbiol.2025026

  10 Insights on

  • Improved Immune Function

  • Low evidence

  BB-12 has been associated with immune-modulating effects, including enhanced immune responses.

  Effect

  Beneficial

  Effect size

  Small

• Probiotic applications of bifidobacteria in poultry: administration methods and microencapsulation techniques.

  • 2024-08-22
  • Review
  • Microbiome research reports 4(3)
  • • Eloy Argañaraz-Martínez
    • María Cristina Apella
    • Adriana Perez Chaia
    • Jaime Daniel Babot

  • PubMed: 41133100
  • DOI: 10.20517/mrr.2025.64

  4 Insights on

  • Improved Immune Function

  • Low evidence

  regulating immune responses through cytokine balance and epithelial barrier reinforcement.

  Effect

  Beneficial

  Effect size

  Moderate