Bifidobacterium animalis subsp. lactis Bi-07 and Improved Lactose Digestion

Research synthesisLow evidenceSmall effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on lactose digestion, with effect sizes ranging from small to moderate (predominantly small). Two of the three studies (including the highest-quality RCT) reported statistically significant benefits. The most studied dose is approximately 10^12 CFU/day, and the evidence primarily comes from individuals with lactose intolerance or maldigestion.

Effective dose range: 10^12 CFU/day
Studied populations: individuals with lactose intolerance or lactose maldigestion

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Additionally, available evidence is overwhelmingly positive, which may reflect publication bias (null-result studies are less likely to be published or indexed). Study durations were not consistently reported, limiting assessment of optimal treatment length.

Generated Jul 12, 2026

Doses used in studies

CFU/day: 1 billion–2000 billion (median 1000.5 billion, IQR 500.8 billion–1500.3 billion) — 2 studies

Safety in these studies

nauseaIncreased riskOR 4.0
Increased odds of nausea were seen with Bi-07 (compared with placebo: 4.0, P = 0.005) in Booster Omega.
from: Bifidobacterium animalis subsp. lactis Bi-07 supports lactose digestion in vitro and in ra
Overall tolerabilityReported
The abstract does not report any adverse events or safety findings.
from: Bifidobacterium animalis subsp. lactis Bi‐07 contributes to increasing lactose digestion:

3 of 3 papersPopulation:

Bifidobacterium animalis subsp. lactis Bi-07 supports lactose digestion in vitro and in randomized, placebo- and lactase-controlled clinical trials
- 2022-12
- RCT
- The American Journal of Clinical Nutrition 116(6)
- - Pia Rasinkangas
  - S. Forssten
  - M. Marttinen
  - A. Ibarra
  - G. Bothe
  - J. Junnila
  - R. Uebelhack
  - Y. Donazzolo
  - A. Ouwehand
- PubMed: 36149331
- DOI: 10.1093/ajcn/nqac264
5 Insights on
- Improved Lactose Digestion
- High evidence
- Clinical
Bi-07 was superior to placebo in reducing BHC [iAUC, parts per million (ppm) ∙ h] in both trials... Bi-07 has high lactase activity, and in 2 clinical trials, it supported lactose digestion in individuals with lactose intolerance.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
2 × 10^12 CFUs
Lactose intolerance and probiotics: from pathophysiological mechanisms to clinical applications.
- 2026-03-17
- Review
- Antonie van Leeuwenhoek 119(4)
- - Tsachi Tsadok Perets
  - Rachel Gingold-Belfer
  - Ram Dickman
- PubMed: 41843249
- DOI: 10.1007/s10482-026-02278-x
3 Insights on
- Improved Lactose Digestion
- Low evidence
This review aims to explore the evidence supporting the use of probiotics as a potential treatment strategy to alleviate the symptoms of lactose intolerance by modulating colonic metabolism and enhancing lactose digestion.
Effect
Beneficial
Effect size
Small
Bifidobacterium animalis subsp. lactis Bi‐07 contributes to increasing lactose digestion: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
- 2020-07
- EFSA Journal 18(7)
- - D. Turck
  - J. Castenmiller
  - S. de Henauw
  - K. Hirsch‐Ernst
  - J. Kearney
  - H. Knutsen
  - A. Maciuk
  - I. Mangelsdorf
  - H. Mcardle
  - A. Naska
  - C. Peláez
  - K. Pentieva
  - F. Thies
  - S. Tsabouri
  - M. Vinceti
  - Jean‐Loui s Bresson
  - A. Siani
- PubMed: 32742434
- DOI: 10.2903/j.efsa.2020.6198
3 Insights on
- Improved Lactose Digestion
- Low evidence
- Clinical
These studies show that consumption of Bi-07 (1012 CFU) increases lactose digestion in individuals with lactose maldigestion
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
10^12 CFU

Bifidobacterium animalis subsp. lactis Bi-07 and Improved Lactose Digestion

Bifidobacterium animalis subsp. lactis Bi-07 supports lactose digestion in vitro and in randomized, placebo- and lactase-controlled clinical trials

Lactose intolerance and probiotics: from pathophysiological mechanisms to clinical applications.

Bifidobacterium animalis subsp. lactis Bi‐07 contributes to increasing lactose digestion: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006