Bifidobacterium bifidum Bb-02 and Improved Gut Microbiota Composition

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Bifidobacterium bifidum Bb-02 on gut microbiota composition, with effect sizes ranging from small to moderate. The only statistically significant finding (p<0.05) showed moderate beneficial effects in an atopic dermatitis mouse model. Evidence is very limited — no dose, duration, or consistent population data are available.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Only one of three studies reported statistical significance; the others are a review and a general article without original data. No human trial data — the only clinical study was in mice.

Generated May 12, 2026

3 of 3 papers

Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.
- 2024-11
- Clinical Trial
- Food science of animal resources 44(6)
- - Gwang Il Kim
  - Hwa Yeong Jeong
  - In Sung Kim
  - Seung Ho Lee
  - Sung Hak Kim
  - Yang Soo Moon
  - Kwang Keun Cho
- PubMed: 39554831
- DOI: 10.5851/kosfa.2024.e100
3 Insights on
- Improved Gut Microbiota Composition
- Moderate evidence
oral administration of the three types of B. bifidum increased Bacteroides spp., Bifidobacterium spp., F. prausnitzii, and Roseburia spp. (p<0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Cell surface polysaccharides in the gut microbiota: occurrence, structure and role.
- 2025-09-02
- Review
- Gut microbes 17(1)
- - Victor Laplanche
  - Immacolata Speciale
  - Cristina De Castro
  - Nathalie Juge
- PubMed: 40898710
- DOI: 10.1080/19490976.2025.2536082
1 Insight on
- Improved Gut Microbiota Composition
- Low evidence
both structurally characterized CPS, CWPS and EPS from both gut commensal bacteria and food-derived bacteria found in the gut. These polysaccharides show high structural diversity and are important for the bacteria to adapt to the GI environment and/or influence host immune response.
Effect
Beneficial
Effect size
Small
Food Bioactive for Gut-Metabolic Axis Regulation and Microbiota Modulation.
- 2025-07-26
- Foods (Basel, Switzerland) 14(15)
- - Xiaoyan Liu
  - Tianjiao Wang
  - Ziwei Liu
  - Guangsen Fan
- PubMed: 40807554
- DOI: 10.3390/foods14152617
4 Insights on
- Improved Gut Microbiota Composition
- Low evidence
consuming Bifidobacterium bifidum Bb-02 ... was associated with increased abundance of beneficial bacteria and improved microbial balance in the gut
Effect
Beneficial
Effect size
Moderate

Bifidobacterium bifidum Bb-02 and Improved Gut Microbiota Composition

Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.

Cell surface polysaccharides in the gut microbiota: occurrence, structure and role.

Food Bioactive for Gut-Metabolic Axis Regulation and Microbiota Modulation.