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Evidence-Based Supplement Research
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Bifidobacterium bifidum Bb-02 and Improved Gut Microbiota Composition

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Bifidobacterium bifidum Bb-02 on gut microbiota composition, with effect sizes ranging from small to moderate. One study (a clinical trial in NC/Nga mice) demonstrated a statistically significant moderate effect, showing increased levels of beneficial genera such as Bacteroides and Bifidobacterium. The evidence is drawn from a small number of studies, including one animal trial and two reviews, with no human intervention data available.

  • Studied populations: NC/Nga mice (an atopic dermatitis model); no human populations studied.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Of the three studies, only one is an interventional trial (in mice), while two are reviews; no human clinical trials are included, limiting direct applicability to humans. Dose, duration, and supplement form were not reported in any study.

Generated Jun 11, 2026
3 of 3 papers
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