Bifidobacterium bifidum Bb-02 and Improved Gut Microbiota Composition

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on gut microbiota composition, with a predominant effect size of moderate. Evidence comes primarily from an animal model (mice with atopic dermatitis) and two reviews; no human clinical trials were identified. No consistent dose or duration data were reported across studies.

Caveats: Available evidence is overwhelmingly positive but based on only 3 studies (including one animal study and two reviews) — conclusions are preliminary and subject to publication bias. Only one study reported statistical significance, suggesting the effect may be smaller than the predominant direction indicates. No human clinical trials were identified, and no dose or form information was available.

Generated Jul 12, 2026

3 of 3 papers

Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.
- 2024-11
- Clinical Trial
- Food science of animal resources 44(6)
- - Gwang Il Kim
  - Hwa Yeong Jeong
  - In Sung Kim
  - Seung Ho Lee
  - Sung Hak Kim
  - Yang Soo Moon
  - Kwang Keun Cho
- PubMed: 39554831
- DOI: 10.5851/kosfa.2024.e100
3 Insights on
- Improved Gut Microbiota Composition
- Moderate evidence
oral administration of the three types of B. bifidum increased Bacteroides spp., Bifidobacterium spp., F. prausnitzii, and Roseburia spp. (p<0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Cell surface polysaccharides in the gut microbiota: occurrence, structure and role.
- 2025-09-02
- Review
- Gut microbes 17(1)
- - Victor Laplanche
  - Immacolata Speciale
  - Cristina De Castro
  - Nathalie Juge
- PubMed: 40898710
- DOI: 10.1080/19490976.2025.2536082
1 Insight on
- Improved Gut Microbiota Composition
- Low evidence
both structurally characterized CPS, CWPS and EPS from both gut commensal bacteria and food-derived bacteria found in the gut. These polysaccharides show high structural diversity and are important for the bacteria to adapt to the GI environment and/or influence host immune response.
Effect
Beneficial
Effect size
Small
Food Bioactive for Gut-Metabolic Axis Regulation and Microbiota Modulation.
- 2025-07-26
- Foods (Basel, Switzerland) 14(15)
- - Xiaoyan Liu
  - Tianjiao Wang
  - Ziwei Liu
  - Guangsen Fan
- PubMed: 40807554
- DOI: 10.3390/foods14152617
4 Insights on
- Improved Gut Microbiota Composition
- Low evidence
consuming Bifidobacterium bifidum Bb-02 ... was associated with increased abundance of beneficial bacteria and improved microbial balance in the gut
Effect
Beneficial
Effect size
Moderate

Bifidobacterium bifidum Bb-02 and Improved Gut Microbiota Composition

Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.

Cell surface polysaccharides in the gut microbiota: occurrence, structure and role.

Food Bioactive for Gut-Metabolic Axis Regulation and Microbiota Modulation.