Bifidobacterium bifidum HA-132 and Reduced All-Cause Mortality

• Effect of probiotics on necrotizing enterocolitis in preterm infants: a network meta-analysis of randomized controlled trials.

  • 2025-03-27
  • Systematic Review · n = 661
  • BMC pediatrics 25(1)
  • • Yu Dai
    • Qinlei Yu
    • Fan Zhang
    • Ke Ma
    • Xiangyun Yan
    • Wenjuan Chen
    • Xiaohui Chen
    • Shushu Li
    • Shuping Han

  • PubMed: 40140789
  • DOI: 10.1186/s12887-025-05469-z

  5 Insights on

  • Reduced All-Cause Mortality

  • High evidence

  Lactobacillus (RR, 0.59; 95% CI: 0.29, 0.98), the combination of Bifidobacterium and Lactobacillus (RR, 0.47; 95% CI: 0.20, 0.87), and the combination of Bifidobacterium, Lactobacillus, and Streptococcus (RR, 0.17; 95% CI: 0.00, 0.84) were the only treatments that significantly reduced all-cause mortality compared to placebo.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Probiotic Supplements Effect on Feeding Tolerance, Growth and Neonatal Morbidity in Extremely Preterm Infants: A Systematic Review and Meta-Analysis.

  • 2025-04-01
  • Meta-Analysis · n = 14
  • Nutrients 17(7)
  • • Sofia Söderquist Kruth
    • Emma Persad
    • Alexander Rakow

  • PubMed: 40218986
  • DOI: 10.3390/nu17071228

  4 Insights on

  • Reduced All-Cause Mortality

  • High evidence
  • Rigorous Journal

  There was a significant reduction in ... all-cause mortality (RR; 0.56, 95% CI; 0.33, 0.93) in the probiotic group.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes