Bifidobacterium bifidum MAK53B66B and Reduced Inflammation Levels

• Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism.

  • 2020-05
  • RCT · n = 7
  • The Journal of Nutritional Biochemistry 79
  • • A. U. Din
    • Adil Hassan
    • Yuan Zhu
    • Kun Zhang
    • Yi Wang
    • Tianhan Li
    • Yang Wang
    • Guixue Wang

  • PubMed: 32145470
  • DOI: 10.1016/j.jnutbio.2020.108353

  15 Insights on

  • Reduced Inflammation Levels

  • Low evidence
  • Animal Study

  Our strain restored the DSS-caused damage by regulating the expression of immune markers and tight junction proteins (TJP) in the colon; briefly by up-regulating ROS-scavenging enzymes (SOD1, SOD2, CAT, and GPX2), anti-inflammatory cytokines (IL-10, PPARγ, IL-6), TJP's (ZO-1, MUC-2, Claudin-3, and E Cadherin-1) and downregulating inflammatory genes (TNF-α, IL-1β).

  Effect

  Beneficial

  Effect size

  Moderate