Across 3 studies, all reported beneficial moderate-sized effects on reduced body fat mass. Two of three studies reached statistical significance. Effects were observed at 8–12 weeks in healthy pre-obese or obesity-prone adults.
Studied populations: pre-obese adults and adults with a tendency for obesity
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). No dose or form data were reported in the included studies, limiting the ability to recommend specific regimens.
Body fat mass and percent body fat were significantly lower in the B-3 group than in the placebo group at weeks 8 and 12 (p<0.05, ANCOVA adjusted with baseline values).