Bifidobacterium plantarum and Improved Gut Microbiome Composition

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on gut microbiome composition, with effect sizes ranging from moderate to large. The evidence is preliminary (only 3 studies, none reported statistical significance). The highest-quality study (RCT in 120 GERD patients) found moderate beneficial effects via metagenomic remodeling. No consistent dose or study duration data were reported.

Studied populations: GERD patients (human RCT) and rats fed a high-cholesterol diet (animal study)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. None of the included studies reported statistical significance. One study was an animal model, and another was a narrative review, limiting the strength of the conclusion. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated May 12, 2026

4 of 4 papers

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.
- 2026-02-17
- RCT
- mSystems 11(2)
- - Yingmeng Li
  - Qiong Li
  - Keyu Quan
  - Yong Xie
  - Ni Yang
  - Teng Ma
  - Longjin Zheng
  - Wei Zhou
  - Yalin Li
  - Hao Jin
  - Zhihong Sun
  - Yongfu Chen
  - Lai-Yu Kwok
  - Nonghua Lu
  - Weifeng Zhu
  - Wenjun Liu
  - Heping Zhang
- PubMed: 41609355
- DOI: 10.1128/msystems.01568-25
8 Insights on
- Improved Gut Microbiome Composition
- High evidence
- Rigorous Journal
Metagenomics revealed enrichment of Bifidobacterium animalis, Lactiplantibacillus plantarum, and Clostridium sp900540255, with reductions in Bacteroides uniformis and Clostridium Q fessum.
Effect
Beneficial
Effect size
Moderate
Probiotic-derived postbiotics: a perspective on next-generation therapeutics.
- 2025-07-17
- Review
- Frontiers in nutrition 12
- - Veilumuthu Pattapulavar
  - Sathiyabama Ramanujam
  - Bhagyashree Kini
  - John Godwin Christopher
- PubMed: 40747333
- DOI: 10.3389/fnut.2025.1624539
7 Insights on
- Improved Gut Microbiome Composition
- Low evidence
The gut microbiome plays a fundamental role in regulating host immunity, metabolism, and overall health. Disruptions to this microbial ecosystem, known as dysbiosis... This review explores... postbiotics... as a promising alternative to live microbial therapy.
Effect
Beneficial
Effect size
Moderate
A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.
- 2026-06
- Food research international (Ottawa, Ont.) 233
- - Rui Xiao
  - Yaqi Yu
  - Deshan Ning
  - Zehua Chen
  - Chuguang Ning
  - Leilei Yu
  - Shumao Cui
  - Jianxin Zhao
  - Gang Wang
  - Yong Zhou
  - Xing Jin
- PubMed: 41956665
- DOI: 10.1016/j.foodres.2026.119002
4 Insights on
- Improved Gut Microbiome Composition
- Low evidence
- Animal Study
16S rRNA gene sequencing revealed increased α-diversity and β-diversity shifts toward control conditions, with enrichment of Lactobacillus, Bifidobacterium, and Akkermansia and suppression of Escherichia-Shigella and Turicibacter.
Effect
Beneficial
Effect size
Moderate
Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.
- 2026-02-20
- BMC microbiology 26(1)
- - Siloni Patial
  - Khem Raj
  - Geeta Shukla
- PubMed: 41721244
- DOI: 10.1186/s12866-026-04840-z
11 Insights on
- Improved Gut Microbiome Composition
- Low evidence
modulated gut microbial composition by increasing beneficial genera (e.g., Ruminococcus, Lactobacillus, Faecalibacterium) and restoring the Bacteroidetes-to-Firmicutes ratio
Effect
Beneficial
Effect size
Large

Bifidobacterium plantarum and Improved Gut Microbiome Composition

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.

Probiotic-derived postbiotics: a perspective on next-generation therapeutics.

A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.

Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.