Bifidobacterium plantarum and Improved Gut Microbiome Composition

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies (1 RCT, 1 review, 1 animal model), all reported beneficial effects on gut microbiome composition, with moderate effect sizes most commonly observed. The only human study involved 120 GERD patients; no dose or duration data were extractable.

Studied populations: GERD patients (one human study); animal model (rats) also showed benefit

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. None of the included studies reported statistically significant findings, so the true effect may be smaller than the predominant direction suggests. Additionally, only one human RCT is included; the other two studies are a review and an animal model, limiting generalizability to humans.

Generated Jul 12, 2026

4 of 4 papers

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.
- 2026-02-17
- RCT
- mSystems 11(2)
- - Yingmeng Li
  - Qiong Li
  - Keyu Quan
  - Yong Xie
  - Ni Yang
  - Teng Ma
  - Longjin Zheng
  - Wei Zhou
  - Yalin Li
  - Hao Jin
  - Zhihong Sun
  - Yongfu Chen
  - Lai-Yu Kwok
  - Nonghua Lu
  - Weifeng Zhu
  - Wenjun Liu
  - Heping Zhang
- PubMed: 41609355
- DOI: 10.1128/msystems.01568-25
8 Insights on
- Improved Gut Microbiome Composition
- High evidence
- Rigorous Journal
Metagenomics revealed enrichment of Bifidobacterium animalis, Lactiplantibacillus plantarum, and Clostridium sp900540255, with reductions in Bacteroides uniformis and Clostridium Q fessum.
Effect
Beneficial
Effect size
Moderate
Probiotic-derived postbiotics: a perspective on next-generation therapeutics.
- 2025-07-17
- Review
- Frontiers in nutrition 12
- - Veilumuthu Pattapulavar
  - Sathiyabama Ramanujam
  - Bhagyashree Kini
  - John Godwin Christopher
- PubMed: 40747333
- DOI: 10.3389/fnut.2025.1624539
7 Insights on
- Improved Gut Microbiome Composition
- Low evidence
The gut microbiome plays a fundamental role in regulating host immunity, metabolism, and overall health. Disruptions to this microbial ecosystem, known as dysbiosis... This review explores... postbiotics... as a promising alternative to live microbial therapy.
Effect
Beneficial
Effect size
Moderate
A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.
- 2026-06
- Food research international (Ottawa, Ont.) 233
- - Rui Xiao
  - Yaqi Yu
  - Deshan Ning
  - Zehua Chen
  - Chuguang Ning
  - Leilei Yu
  - Shumao Cui
  - Jianxin Zhao
  - Gang Wang
  - Yong Zhou
  - Xing Jin
- PubMed: 41956665
- DOI: 10.1016/j.foodres.2026.119002
4 Insights on
- Improved Gut Microbiome Composition
- Low evidence
- Animal Study
16S rRNA gene sequencing revealed increased α-diversity and β-diversity shifts toward control conditions, with enrichment of Lactobacillus, Bifidobacterium, and Akkermansia and suppression of Escherichia-Shigella and Turicibacter.
Effect
Beneficial
Effect size
Moderate
Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.
- 2026-02-20
- BMC microbiology 26(1)
- - Siloni Patial
  - Khem Raj
  - Geeta Shukla
- PubMed: 41721244
- DOI: 10.1186/s12866-026-04840-z
11 Insights on
- Improved Gut Microbiome Composition
- Low evidence
modulated gut microbial composition by increasing beneficial genera (e.g., Ruminococcus, Lactobacillus, Faecalibacterium) and restoring the Bacteroidetes-to-Firmicutes ratio
Effect
Beneficial
Effect size
Large

Bifidobacterium plantarum and Improved Gut Microbiome Composition

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.

Probiotic-derived postbiotics: a perspective on next-generation therapeutics.

A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.

Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.