Bifidobacterium plantarum and Improved Gut Microbiome Composition

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Bifidobacterium plantarum on gut microbiome composition, with moderate to large effect sizes. The highest-quality evidence (a randomized controlled trial in 120 GERD patients) showed moderate beneficial effects, including enrichment of beneficial bacteria and reductions in potentially harmful taxa. No studies reported statistically significant findings, and doses were not reported.

Studied populations: GERD patients

Caveats: Only 3 studies exist, none reported statistical significance, and one study was in rats and another was a narrative review — limiting the strength of the evidence. Doses were not reported across studies, making dose-response conclusions impossible.

Generated May 10, 2026

4 of 4 papers

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.
- 2026-02-17
- RCT
- mSystems 11(2)
- - Yingmeng Li
  - Qiong Li
  - Keyu Quan
  - Yong Xie
  - Ni Yang
  - Teng Ma
  - Longjin Zheng
  - Wei Zhou
  - Yalin Li
  - Hao Jin
  - Zhihong Sun
  - Yongfu Chen
  - Lai-Yu Kwok
  - Nonghua Lu
  - Weifeng Zhu
  - Wenjun Liu
  - Heping Zhang
- PubMed: 41609355
- DOI: 10.1128/msystems.01568-25
8 Insights on
- Improved Gut Microbiome Composition
- High evidence
- Rigorous Journal
Metagenomics revealed enrichment of Bifidobacterium animalis, Lactiplantibacillus plantarum, and Clostridium sp900540255, with reductions in Bacteroides uniformis and Clostridium Q fessum.
Effect
Beneficial
Effect size
Moderate
Probiotic-derived postbiotics: a perspective on next-generation therapeutics.
- 2025-07-17
- Review
- Frontiers in nutrition 12
- - Veilumuthu Pattapulavar
  - Sathiyabama Ramanujam
  - Bhagyashree Kini
  - John Godwin Christopher
- PubMed: 40747333
- DOI: 10.3389/fnut.2025.1624539
7 Insights on
- Improved Gut Microbiome Composition
- Low evidence
The gut microbiome plays a fundamental role in regulating host immunity, metabolism, and overall health. Disruptions to this microbial ecosystem, known as dysbiosis... This review explores... postbiotics... as a promising alternative to live microbial therapy.
Effect
Beneficial
Effect size
Moderate
Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.
- 2026-02-20
- BMC microbiology 26(1)
- - Siloni Patial
  - Khem Raj
  - Geeta Shukla
- PubMed: 41721244
- DOI: 10.1186/s12866-026-04840-z
11 Insights on
- Improved Gut Microbiome Composition
- Low evidence
modulated gut microbial composition by increasing beneficial genera (e.g., Ruminococcus, Lactobacillus, Faecalibacterium) and restoring the Bacteroidetes-to-Firmicutes ratio
Effect
Beneficial
Effect size
Large
A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.
- 2026-06
- Food research international (Ottawa, Ont.) 233
- - Rui Xiao
  - Yaqi Yu
  - Deshan Ning
  - Zehua Chen
  - Chuguang Ning
  - Leilei Yu
  - Shumao Cui
  - Jianxin Zhao
  - Gang Wang
  - Yong Zhou
  - Xing Jin
- PubMed: 41956665
- DOI: 10.1016/j.foodres.2026.119002
4 Insights on
- Improved Gut Microbiome Composition
- Low evidence
- Animal Study
16S rRNA gene sequencing revealed increased α-diversity and β-diversity shifts toward control conditions, with enrichment of Lactobacillus, Bifidobacterium, and Akkermansia and suppression of Escherichia-Shigella and Turicibacter.
Effect
Beneficial
Effect size
Moderate

Bifidobacterium plantarum and Improved Gut Microbiome Composition

Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.

Probiotic-derived postbiotics: a perspective on next-generation therapeutics.

Modulation of gut-heart axis by synbiotic (Lactiplantibacillus plantarum M10 and Isomaltose) in high cholesterol diet induced atherosclerotic murine model.

A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.