Bifidobacterium plantarum and Reduced CRKP Colonization

• Microbiome-mediated colonization resistance to carbapenem-resistant Klebsiella pneumoniae in ICU patients.

  • 2025-08-09
  • Observational
  • NPJ biofilms and microbiomes 11(1)
  • • Jing Yang
    • Yi Zhou
    • Aiping Du
    • Zhongwei Zhang
    • Bo Wang
    • Yongming Tian
    • Huan Liu
    • Lin Cai
    • Fang Pang
    • Yumei Li
    • Chunhua Du
    • Xijun Wu
    • Cong Yan
    • Wei Wu
    • Min Jiang
    • Ke Shen
    • Chi Zhang
    • Yu Feng
    • Yan Kang
    • Bairong Shen
    • Zhiyong Zong

  • PubMed: 40783567
  • DOI: 10.1038/s41522-025-00791-x

  2 Insights on

  • Reduced CRKP Colonization

  • Low evidence

  Both in vitro and in vivo experiments revealed that Lactiplantibacillus plantarum and Bifidobacterium longum as significant contributors to the decolonization of CRKP. Furthermore, we showed that probiotic supplementation or FMT significantly improved CRKP colonization resistance.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes