Across 3 studies, all reported beneficial effects of Bifidobacterium plantarum on reducing oxidative stress, with effect sizes ranging from small to moderate. The evidence base is very limited and preliminary, and no specific dose, form, or population data were consistently reported. Duration of supplementation was not reported across studies.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All 3 studies reported beneficial effects, but none reached statistical significance, and 2 were narrative reviews with no original data. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).
Phytoantioxidants such as polyphenols directly neutralize I/R-induced reactive oxygen species (ROS), which promote microvascular recovery and neuronal survival.
Lacocaseibacillus casei, Lactiplantibacillus plantarum, and Bifidobacterium bifidum mitigate CRC by lowering oxidative stress and lipid peroxidation
synbiotic supplementation enhanced antioxidant levels (SOD and GSH), decreased oxidants (MDA)