Across 3 studies, all reported beneficial effects of Bifidobacterium plantarum on reducing oxidative stress, with effect sizes ranging from small to moderate. No consistent dose or population data were available across studies.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). None of the included studies reported statistically significant findings, and one study was conducted on an animal model.
Phytoantioxidants such as polyphenols directly neutralize I/R-induced reactive oxygen species (ROS), which promote microvascular recovery and neuronal survival.
Lacocaseibacillus casei, Lactiplantibacillus plantarum, and Bifidobacterium bifidum mitigate CRC by lowering oxidative stress and lipid peroxidation
synbiotic supplementation enhanced antioxidant levels (SOD and GSH), decreased oxidants (MDA)