Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

Research synthesisModerate evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies (2 RCTs, 2 reviews), all reported beneficial effects of Lactobacillus acidophilus L-92 on atopic dermatitis symptoms. The two RCTs showed large, statistically significant improvements, while the reviews reported moderate benefits. Evidence is strongest for adults and children with clinically diagnosed atopic dermatitis, primarily in Japanese populations.

Studied populations: Japanese adults and children with clinically diagnosed atopic dermatitis

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Additionally, only two primary RCTs (both in Japanese populations) have been conducted, and no dose or form data are available, limiting the specificity of recommendations.

Generated Jul 11, 2026

Doses used in studies

CFU/day: 1 (median 1, IQR 1–1) — 1 study

4 of 4 papersPopulation:

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial
- 2015-04-16
- RCT · n = 49
- International Archives of Allergy and Immunology 165(4)
- - Y. Inoue
  - T. Kambara
  - Naoko Murata
  - J. Komori-Yamaguchi
  - S. Matsukura
  - Yukitoshi Takahashi
  - Z. Ikezawa
  - M. Aihara
- PubMed: 25660281
- DOI: 10.1159/000369806
3 Insights on
- Improved Atopic Dermatitis Symptoms
- High evidence
- Clinical
The group that ingested L-92 had lower SCORAD scores than the controls (p = 0.002).
Effect
Beneficial
Effect size
Large
Significant
Yes
Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children
- 2010-09-21
- RCT
- International Archives of Allergy and Immunology 154(3)
- - S. Torii
  - Akiko Torii
  - K. Itoh
  - A. Urisu
  - A. Terada
  - T. Fujisawa
  - Kazue Yamada
  - Hiromi Suzuki
  - Y. Ishida
  - F. Nakamura
  - H. Kanzato
  - D. Sawada
  - A. Nonaka
  - M. Hatanaka
  - S. Fujiwara
- PubMed: 20861645
- DOI: 10.1159/000321110
6 Insights on
- Improved Atopic Dermatitis Symptoms
- High evidence
- Clinical
Orally administered L-92 significantly ameliorated the symptoms of AD in Japanese children.
Effect
Beneficial
Effect size
Large
Significant
Yes
The crosstalk between probiotics and T cell immunity.
- 2025-10-23
- Review
- Frontiers in immunology 16
- - Yuanyuan Liu
  - Xu Cao
  - Hongwei Liu
  - Wencan Zhang
- PubMed: 41208998
- DOI: 10.3389/fimmu.2025.1695840
4 Insights on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to alleviate allergic symptoms, including atopic dermatitis, in human clinical studies.
Effect
Beneficial
Effect size
Moderate
Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.
- 2025-05-07
- Review
- Microorganisms 13(5)
- - Valentina Origüela
  - Alvaro Lopez-Zaplana
- PubMed: 40431257
- DOI: 10.3390/microorganisms13051084
7 Insights on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to improve the symptoms of atopic dermatitis in both adults and children.
Effect
Beneficial
Effect size
Moderate

Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children

The crosstalk between probiotics and T cell immunity.

Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.