Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

Research synthesisLow evidenceLarge effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on atopic dermatitis symptoms, with effect sizes ranging from moderate to large. Two randomized controlled trials in adults and children with clinical atopic dermatitis found statistically significant improvements in SCORAD scores. The evidence base is small, and no consistent dose range or treatment duration could be extracted from the available studies.

Studied populations: Adults and children with atopic dermatitis (clinical populations)

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Dose and treatment duration were not consistently reported, limiting practical application. Two of the 4 studies are reviews that do not provide independent data.

Generated Jun 11, 2026

Doses used in studies

CFU/day: 1 (median 1, IQR 1–1) — 1 study

4 of 4 papersPopulation:

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial
- 2015-04-16
- RCT · n = 49
- International Archives of Allergy and Immunology 165(4)
- - Y. Inoue
  - T. Kambara
  - Naoko Murata
  - J. Komori-Yamaguchi
  - S. Matsukura
  - Yukitoshi Takahashi
  - Z. Ikezawa
  - M. Aihara
- PubMed: 25660281
- DOI: 10.1159/000369806
3 Insights on
- Improved Atopic Dermatitis Symptoms
- High evidence
- Clinical
The group that ingested L-92 had lower SCORAD scores than the controls (p = 0.002).
Effect
Beneficial
Effect size
Large
Significant
Yes
Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children
- 2010-09-21
- RCT
- International Archives of Allergy and Immunology 154(3)
- - S. Torii
  - Akiko Torii
  - K. Itoh
  - A. Urisu
  - A. Terada
  - T. Fujisawa
  - Kazue Yamada
  - Hiromi Suzuki
  - Y. Ishida
  - F. Nakamura
  - H. Kanzato
  - D. Sawada
  - A. Nonaka
  - M. Hatanaka
  - S. Fujiwara
- PubMed: 20861645
- DOI: 10.1159/000321110
6 Insights on
- Improved Atopic Dermatitis Symptoms
- High evidence
- Clinical
Orally administered L-92 significantly ameliorated the symptoms of AD in Japanese children.
Effect
Beneficial
Effect size
Large
Significant
Yes
The crosstalk between probiotics and T cell immunity.
- 2025-10-23
- Review
- Frontiers in immunology 16
- - Yuanyuan Liu
  - Xu Cao
  - Hongwei Liu
  - Wencan Zhang
- PubMed: 41208998
- DOI: 10.3389/fimmu.2025.1695840
4 Insights on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to alleviate allergic symptoms, including atopic dermatitis, in human clinical studies.
Effect
Beneficial
Effect size
Moderate
Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.
- 2025-05-07
- Review
- Microorganisms 13(5)
- - Valentina Origüela
  - Alvaro Lopez-Zaplana
- PubMed: 40431257
- DOI: 10.3390/microorganisms13051084
7 Insights on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to improve the symptoms of atopic dermatitis in both adults and children.
Effect
Beneficial
Effect size
Moderate

Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children

The crosstalk between probiotics and T cell immunity.

Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.