Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

• Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial

  • 2015-04-16
  • RCT · n = 49
  • International Archives of Allergy and Immunology 165(4)
  • • Y. Inoue
    • T. Kambara
    • Naoko Murata
    • J. Komori-Yamaguchi
    • S. Matsukura
    • Yukitoshi Takahashi
    • Z. Ikezawa
    • M. Aihara

  • PubMed: 25660281
  • DOI: 10.1159/000369806

  3 Insights on

  • Improved Atopic Dermatitis Symptoms

  • High evidence

  The group that ingested L-92 had lower SCORAD scores than the controls (p = 0.002).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children

  • 2010-09-21
  • RCT
  • International Archives of Allergy and Immunology 154(3)
  • • S. Torii
    • Akiko Torii
    • K. Itoh
    • A. Urisu
    • A. Terada
    • T. Fujisawa
    • Kazue Yamada
    • Hiromi Suzuki
    • Y. Ishida
    • F. Nakamura
    • H. Kanzato
    • D. Sawada
    • A. Nonaka
    • M. Hatanaka
    • S. Fujiwara

  • PubMed: 20861645
  • DOI: 10.1159/000321110

  5 Insights on

  • Improved Atopic Dermatitis Symptoms

  • High evidence

  Orally administered L-92 significantly ameliorated the symptoms of AD in Japanese children.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• The crosstalk between probiotics and T cell immunity.

  • 2025-10-23
  • Review
  • Frontiers in immunology 16
  • • Yuanyuan Liu
    • Xu Cao
    • Hongwei Liu
    • Wencan Zhang

  • PubMed: 41208998
  • DOI: 10.3389/fimmu.2025.1695840

  4 Insights on

  • Improved Atopic Dermatitis Symptoms

  • Low evidence

  Lactobacillus acidophilus L-92 has been reported to alleviate allergic symptoms, including atopic dermatitis, in human clinical studies.

  Effect

  Beneficial

  Effect size

  Moderate

• Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.

  • 2025-05-07
  • Review
  • Microorganisms 13(5)
  • • Valentina Origüela
    • Alvaro Lopez-Zaplana

  • PubMed: 40431257
  • DOI: 10.3390/microorganisms13051084

  7 Insights on

  • Improved Atopic Dermatitis Symptoms

  • Low evidence

  Lactobacillus acidophilus L-92 has been reported to improve the symptoms of atopic dermatitis in both adults and children.

  Effect

  Beneficial

  Effect size

  Moderate