Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

Research synthesisModerate evidenceLarge effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies (2 randomized controlled trials and 2 reviews), all reported beneficial effects of Lactobacillus acidophilus L-92 on atopic dermatitis symptoms. The two RCTs both showed large, statistically significant improvements in SCORAD scores in Japanese adults (p=0.002) and children. The two reviews provide additional support, but the evidence base is small and all studies show positive results, raising concern for publication bias.

Studied populations: Adults and children with atopic dermatitis (Japanese populations studied)

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. No dose or treatment duration data were consistently reported across studies, limiting the ability to recommend a specific regimen.

Generated May 12, 2026

Doses used in studies

CFU/day: 1 (median 1, IQR 1–1) — 1 study

4 of 4 papersPopulation:

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial
- 2015-04-16
- RCT · n = 49
- International Archives of Allergy and Immunology 165(4)
- - Y. Inoue
  - T. Kambara
  - Naoko Murata
  - J. Komori-Yamaguchi
  - S. Matsukura
  - Yukitoshi Takahashi
  - Z. Ikezawa
  - M. Aihara
- PubMed: 25660281
- DOI: 10.1159/000369806
3 Insights on
- Improved Atopic Dermatitis Symptoms
- High evidence
- Clinical
The group that ingested L-92 had lower SCORAD scores than the controls (p = 0.002).
Effect
Beneficial
Effect size
Large
Significant
Yes
Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children
- 2010-09-21
- RCT
- International Archives of Allergy and Immunology 154(3)
- - S. Torii
  - Akiko Torii
  - K. Itoh
  - A. Urisu
  - A. Terada
  - T. Fujisawa
  - Kazue Yamada
  - Hiromi Suzuki
  - Y. Ishida
  - F. Nakamura
  - H. Kanzato
  - D. Sawada
  - A. Nonaka
  - M. Hatanaka
  - S. Fujiwara
- PubMed: 20861645
- DOI: 10.1159/000321110
6 Insights on
- Improved Atopic Dermatitis Symptoms
- High evidence
- Clinical
Orally administered L-92 significantly ameliorated the symptoms of AD in Japanese children.
Effect
Beneficial
Effect size
Large
Significant
Yes
The crosstalk between probiotics and T cell immunity.
- 2025-10-23
- Review
- Frontiers in immunology 16
- - Yuanyuan Liu
  - Xu Cao
  - Hongwei Liu
  - Wencan Zhang
- PubMed: 41208998
- DOI: 10.3389/fimmu.2025.1695840
4 Insights on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to alleviate allergic symptoms, including atopic dermatitis, in human clinical studies.
Effect
Beneficial
Effect size
Moderate
Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.
- 2025-05-07
- Review
- Microorganisms 13(5)
- - Valentina Origüela
  - Alvaro Lopez-Zaplana
- PubMed: 40431257
- DOI: 10.3390/microorganisms13051084
7 Insights on
- Improved Atopic Dermatitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to improve the symptoms of atopic dermatitis in both adults and children.
Effect
Beneficial
Effect size
Moderate

Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Symptoms

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial

Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children

The crosstalk between probiotics and T cell immunity.

Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.