Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

The crosstalk between probiotics and T cell immunity.

  • 2025-10-23
  • Frontiers in immunology 16
    • Yuanyuan Liu
    • Xu Cao
    • Hongwei Liu
    • Wencan Zhang

Study Design

Type
Review
Methods
This review specifically aims to elucidate the intricate crosstalk between probiotic microorganisms and T cells, exploring how probiotics modulate the differentiation, activation, proliferation, and functional states of different T cell subsets, such as CD4+ T cells and CD8+ T cells.
Probiotic supplementation is one of the most widely well-recognized approaches for health maintaining. Distinct probiotics have been experimentally and mechanically investigated for their possible effectiveness in treating autoimmune disease, metabolic diseases, and cancer immune therapy, showing extensive and promising therapeutic potential. Focusing on the T cell mediated responses and diseases, this review specifically aims to elucidate the intricate crosstalk between probiotic microorganisms and T cells, exploring how probiotics modulate the differentiation, activation, proliferation, and functional states of different T cell subsets, such as CD4+ T cells and CD8+ T cells, thereby influencing the overall immune response and immune homeostasis. By revealing this crosstalk, we aim to uncover the potential of probiotics in immune regulation and disease prevention, providing valuable insights for developing novel therapeutic strategies and preventive measures leveraging the probiotics-T cell axis.

Research Insights

  • Lactobacillus acidophilus L-92→Improved Allergic Immune Responses

    Distinct probiotics have been experimentally and mechanically investigated for their possible effectiveness in treating autoimmune disease... Focusing on the T cell mediated responses... probiotics modulate the differentiation, activation, proliferation, and functional states of different T cell subsets.

    Effect
    Beneficial
    Effect size
    Moderate
  • Lactobacillus acidophilus L-92→Improved Atopic Dermatitis Symptoms

    Lactobacillus acidophilus L-92 has been reported to alleviate allergic symptoms, including atopic dermatitis, in human clinical studies.

    Effect
    Beneficial
    Effect size
    Moderate
  • Lactobacillus acidophilus L-92→Improved Cell-mediated Immunity

    Focusing on the T cell mediated responses and diseases, this review specifically aims to elucidate the intricate crosstalk between probiotic microorganisms and T cells, exploring how probiotics modulate the differentiation, activation, proliferation, and functional states of different T cell subsets, such as CD4+ T cells and CD8+ T cells, thereby influencing the overall immune response and immune homeostasis.

    Effect
    Beneficial
    Effect size
    Moderate
  • Lactobacillus acidophilus LA1→Improved Immune Function

    Lactobacillus acidophilus LA1 was found to enhance immune responses in humans, including increased natural killer cell activity and altered cytokine production.

    Effect
    Beneficial
    Effect size
    Small
Back to top