Lactobacillus acidophilus L-92 and Reduced Severity of Allergic Rhinitis Symptoms

Research synthesisLow evidenceModerate effect10 studies · 10 beneficial · 0 neutral · 0 harmful

Across 10 studies, all reported beneficial effects of Lactobacillus acidophilus L-92 on reducing allergic rhinitis severity, with the predominant effect size being moderate. However, only 1 study reported statistically significant findings, and most studies were reviews with low evidence scores.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jun 11, 2026

10 of 10 papers

The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.
- 2026-01
- Systematic Review
- Integrative cancer therapies 25
- - Sarah Benna-Doyle
  - Suzanne Grant
  - Alison Maunder
  - Jing Liu
  - Melik Ibrahim
  - Adele Cave
  - Chhiti Pandey
  - Monica Tang
  - Eng-Siew Koh
  - Geoff Delaney
  - Deep Jyoti Bhuyan
  - Victoria Choi
  - Ki Kwon
  - Maria Gonzalez
  - Susannah Graham
  - Ashanya Malalasekera
  - Carolyn Ee
- PubMed: 41482855
- DOI: 10.1177/15347354251405267
13 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- High evidence
Lactobacillus acidophilus L-92 has been reported to improve allergic symptoms in some studies, but the abstract provided does not describe specific clinical outcomes for this supplement.
Effect
Beneficial
Effect size
Small
Bacteriophages, Antibiotics and Probiotics: Exploring the Microbial Battlefield of Colorectal Cancer.
- 2025-08-13
- Review
- International journal of molecular sciences 26(16)
- - Cristian Constantin Volovat
  - Mihai Andrei Cosovanu
  - Madalina-Raluca Ostafe
  - Iolanda Georgiana Augustin
  - Constantin Volovat
  - Bogdan Georgescu
  - Simona Ruxandra Volovat
- PubMed: 40869155
- DOI: 10.3390/ijms26167837
1 Insight on
- Reduced Severity of Allergic Rhinitis Symptoms
- Moderate evidence
- Rigorous Journal
consuming Lactobacillus acidophilus L-92 has been reported to improve symptoms of allergic rhinitis in randomized controlled trials
Effect
Beneficial
Effect size
Moderate
Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.
- 2026-03-24
- Review
- Frontiers in immunology 16
- - Mohamed T El-Saadony
  - Ahmed M Saad
  - Mahmoud Sitohy
  - Samar Sami Alkafaas
  - Mthokozisi Dladla
  - Soumya Ghosh
  - Dina Mostafa Mohammed
  - Essam H Ibrahim
  - Mohamed A Fahmy
  - Amr Elkelish
  - Synan F AbuQamar
  - Khaled A El-Tarabily
- PubMed: 41953220
- DOI: 10.3389/fimmu.2025.1713426
10 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
probiotics including Lactobacillus acidophilus L-92 have been reported to improve symptoms of allergic rhinitis
Effect
Beneficial
Effect size
Moderate
Unraveling the dynamic changes in the intestinal microbiome: impacts on pre-weaning calf health and productivity.
- 2026-03-04
- Review
- Journal of animal science and biotechnology 17(1)
- - Yang Song
  - Shubo Wen
  - Le Luo Guan
- PubMed: 41776699
- DOI: 10.1186/s40104-026-01354-6
6 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to help alleviate symptoms of atopic disease, including allergic rhinitis, in human studies.
Effect
Beneficial
Effect size
Moderate
Bacterial cell envelope components of gut commensals: effects in host-microbe interaction.
- 2026-01-30
- Review
- Annals of medicine 58(1)
- - Thaís Vilela Rodrigues
  - Luís Lima de Jesus
  - Philippe Langella
  - Siomar de Castro Soares
  - Gwénaël Jan
  - Vasco Ariston de Carvalho Azevedo
  - Jean-Marc Chatel
- PubMed: 41614625
- DOI: 10.1080/07853890.2026.2618429
4 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to reduce symptoms of Japanese cedar pollinosis and perennial allergic rhinitis in human studies.
Effect
Beneficial
Effect size
Small
Application of Probiotics in Foods: A Comprehensive Review of Benefits, Challenges, and Future Perspectives.
- 2025-09-02
- Review
- Foods (Basel, Switzerland) 14(17)
- - Mirjana Ž Grujović
  - Teresa Semedo-Lemsaddek
  - Katarina G Marković
- PubMed: 40941204
- DOI: 10.3390/foods14173088
3 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
supplementation with Lactobacillus acidophilus L-92 significantly improved total nasal symptom scores, quality of life, and some immunological markers in patients with Japanese cedar pollinosis
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Certain fermented dairy foods as a source of multibiotics and multimetabolites: a comprehensive review.
- 2025-11-06
- Review
- Frontiers in nutrition 12
- - Duygu Ağagündüz
  - Yasemin Ertaş Öztürk
  - Büşra Ayhan
  - Tuğçe Bulmuş-Tüccar
  - Çiler Özenir
  - Nazlıcan Erdoğan Gövez
  - Yesim Ozogul
  - Tuba Esatbeyoglu
  - Fatih Ozogul
- PubMed: 41280398
- DOI: 10.3389/fnut.2025.1678150
5 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
Consumption of Lactobacillus acidophilus L-92 has been associated with alleviation of symptoms in subjects with allergic rhinitis.
Effect
Beneficial
Effect size
Moderate
Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.
- 2025-05-07
- Review
- Microorganisms 13(5)
- - Valentina Origüela
  - Alvaro Lopez-Zaplana
- PubMed: 40431257
- DOI: 10.3390/microorganisms13051084
7 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
Lactobacillus acidophilus L-92 has been reported to alleviate symptoms and improve quality of life in patients with allergic rhinitis.
Effect
Beneficial
Effect size
Moderate
The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals.
- 2025-10-15
- Review
- Animals : an open access journal from MDPI 15(20)
- - Sorin Marian Mârza
  - Camelia Munteanu
  - Ionel Papuc
  - Lăcătuş Radu
  - Robert Cristian Purdoiu
- PubMed: 41153915
- DOI: 10.3390/ani15202986
4 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
Probiotics, including Lactobacillus acidophilus L-92, have been reported to improve symptoms of allergic rhinitis and other allergic diseases in clinical studies.
Effect
Beneficial
Effect size
Moderate
Efficacy of Lactobacillus and Bifidobacterium in Allergic Rhinitis: A Narrative Review.
- 2025-07-10
- Review
- Cureus 17(7)
- - Tejaswi Mishra
  - Ksbs Krishna Sasanka
  - Sree Sudha Ty
  - Gulistan Bano
  - Swaha Panda
  - M Mohan Raj
  - Himel Mondal
  - Pradosh Kumar Sarangi
- PubMed: 40786436
- DOI: 10.7759/cureus.87644
4 Insights on
- Reduced Severity of Allergic Rhinitis Symptoms
- Low evidence
Clinical data, though heterogeneous, suggest that selected strains may improve nasal symptoms and quality of life in both adult and pediatric populations.
Effect
Beneficial
Effect size
Moderate