Lactobacillus acidophilus MAK32L61A and Improved Immune Response

• Lactobacillus acidophilus LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota.

  • 2022-08-03
  • Clinical Trial
  • Food & Function 13(15)
  • • L. Xue
    • Zongqi Li
    • Jiabao Xue
    • Huiting Wang
    • Tao Wu
    • R. Liu
    • Wenjie Sui
    • M. Zhang

  • PubMed: 35793105
  • DOI: 10.1039/d1fo04331e

  8 Insights on

  • Improved Immune Response

  • Low evidence
  • Animal Study

  And it could enhance the immune response of the body through the TLR4/NF-κB signaling pathway.

  Effect

  Beneficial

  Effect size

  Large

• Effects of Lactobacillus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157

  • 2021-09
  • RCT · n = 360
  • Poultry Science 100(9)
  • • Zhengke Wu
    • Kexin Yang
    • A. Zhang
    • Wenhuan Chang
    • A. Zheng
    • Zhi-Min Chen
    • Huiyi Cai
    • Guohua Liu

  • PubMed: 34280647
  • DOI: 10.1016/j.psj.2021.101323

  14 Insights on

  • Improved Immune Response

  • Low evidence
  • Rigorous Journal
  • Animal Study

  L. acidophilus supplementation reduced the serum CRP, DAO, and LPS levels at 14 d and 21 d; upregulated the mRNA expression of occludin and ZO-1 in the jejunum and ileum, and downregulated the mRNA expression of iNOS, IL-8, and IL-1β in the jejunum in E. coli challenged birds at 21 d (P < 0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Dietary supplementation with Lactobacillus acidophilus enhanced the growth, gut morphometry, antioxidant capacity, and the immune response in juveniles of the common carp, Cyprinus carpio

  • 2020-03-30
  • RCT · n = 240
  • Fish Physiology and Biochemistry 46(4)
  • • I. Adeshina
    • M. I. Abubakar
    • Bunmi Elizabeth Ajala

  • PubMed: 32232615
  • DOI: 10.1007/s10695-020-00796-7

  6 Insights on

  • Improved Immune Response

  • Low evidence
  • Animal Study

  Transforming growth factor beta (TGFβ), interleukin 8 (IL-8), and tumor necrosis factor alpha (TNF-alpha) were significantly stimulated.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes