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Abstract

We studied the effects of Lactobacillus acidophilus (L. acidophilus) on the growth performance, intestinal morphology, barrier function, and immune response of broilers challenged with Escherichia coli O157 (E. Coli). A total of 360 1-day-old Cobb male broilers were tested in a 3 × 2 factorial arrangement with 3 dietary L. acidophilus levels (0, 5 × 108 CFU/kg, and 10 × 108 CFU/kg of diet) and 2 disease challenge treatments (control or E. coli challenged). Results showed that E. coli challenge decreased the ADG, ADFI, and BW of broilers from 15 to 21 d (P < 0.05), increased the jejunum intestinal wall thickness, and significantly increased the mortality rate. E. coli challenge significantly (P < 0.05) decreased the serum IgA and IgM contents and peripheral blood CD3+ T cell counts (P < 0.05), increased the serum CRP, DAO, and LPS levels at 21 d; upregulated the mRNA expression of iNOS, IL-8, IL-1β in the jejunum and iNOS in the spleen, and downregulated the occludin and ZO-1 mRNA expression in the ileum at 21 d compared with uninfected birds (P < 0.05). Dietary L. acidophilus supplementation consistently showed higher BW, ADG, ADFI, and jejunum and ileum V:C ratio at 14 d and 21 d in the presence and absence of E. coli challenge (P < 0.05). L. acidophilus supplementation reduced the mortality rate caused by E. coli challenge (P < 0.05), decreased the serum CRP, DAO, and LPS levels at 14 d and 21 d; upregulated the mRNA expression of occludin and ZO-1 in the jejunum and ileum, and downregulated the mRNA expression of iNOS, IL-8, and IL-1β in the jejunum in E. coli challenged birds at 21 d (P < 0.05). Dietary supplementation with L. acidophilus can improve the growth performance, intestinal health, and survival of broilers challenged with E. coli.

Keywords: Escherichia coli; Lactobacillus acidophilus; broiler; intestinal barrier function.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilusImproved Gastrointestinal HealthBeneficial
Large
Lactobacillus acidophilusImproved Growth PerformanceBeneficial
Large
Lactobacillus acidophilusImproved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilusModulated Inflammatory ResponseBeneficial
Large
Lactobacillus acidophilusReduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus HA-122Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus HA-122Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus acidophilus HA-122Modulated Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus HA-122Reduced Inflammatory MarkersBeneficial
Moderate
Lactobacillus acidophilus L-92Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus L-92Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus LA-02Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus LA-02Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus LA-02Improved Intestinal FunctionBeneficial
Large
Lactobacillus acidophilus LA-02Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus LA1Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus LA1Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus LA1Improved Intestinal FunctionBeneficial
Large
Lactobacillus acidophilus LA1Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus La-14Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus La-14Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus La-14Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus La-14Reduced Inflammation LevelsBeneficial
Large
Lactobacillus acidophilus LA-5Improved Cell Survival RatesBeneficial
Moderate
Lactobacillus acidophilus LA-5Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus LA-5Improved Intestinal FunctionBeneficial
Large
Lactobacillus acidophilus LA85Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus LA85Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus LA85Improved Intestinal FunctionBeneficial
Large
Lactobacillus acidophilus LA85Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AImproved Gastrointestinal HealthBeneficial
Large
Lactobacillus acidophilus MAK32L61AImproved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus MAK32L61AReduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Improved Gastrointestinal HealthBeneficial
Large
Lactobacillus acidophilus NCIMB 30333Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus NCIMB 30333Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus NCIMB 30333Reduced Inflammatory ResponseBeneficial
Moderate
Lactobacillus acidophilus R0418Improved Gastrointestinal HealthBeneficial
Large
Lactobacillus acidophilus R0418Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus R0418Improved Survival RateBeneficial
Large
Lactobacillus acidophilus SD-5212Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus SD-5212Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus SD-5212Improved Intestinal FunctionBeneficial
Large
Lactobacillus acidophilus SD-5212Reduced Inflammatory ResponseBeneficial
Moderate
Lactobacillus acidophilus SD-5212Reduced Mortality RateBeneficial
Large
Lactobacillus acidophilus UALa01Improved Growth PerformanceBeneficial
Large
Lactobacillus acidophilus UALa01Improved Immune ResponseBeneficial
Moderate
Lactobacillus acidophilus UALa01Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Colitis-Related MortalityBeneficial
Moderate
Lactobacillus acidophilus UALa01Reduced Inflammatory ResponseBeneficial
Moderate

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