Lactobacillus acidophilus UALa01 and Reduced Inflammatory Response

• The anti-apoptotic and anti-inflammatory effect of Lactobacillus acidophilus on Shigella sonnei and Vibrio cholerae interaction with intestinal epithelial cells: A comparison between invasive and non-invasive bacteria

  • 2018-06-06
  • PLOS ONE 13(6)
  • • Shabnam Zeighamy Alamdary
    • B. Bakhshi
    • S. Soudi

  • PubMed: 29874233
  • DOI: 10.1371/journal.pone.0196941

  3 Insights on

  • Reduced Inflammatory Response

  • Low evidence
  • Rigorous Journal

  Statistical analysis revealed that L. acidophilus in S. sonnei infected cells was able to reduce pro-inflammatory immune responses (TNF-α, IL-8 and IL-1β) and NO and PGE2 secretion more strongly compared with V. cholerae infected cells.

  Effect

  Beneficial

  Effect size

  Moderate

• Effects of Lactobacillus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157

  • 2021-09
  • RCT · n = 360
  • Poultry Science 100(9)
  • • Zhengke Wu
    • Kexin Yang
    • A. Zhang
    • Wenhuan Chang
    • A. Zheng
    • Zhi-Min Chen
    • Huiyi Cai
    • Guohua Liu

  • PubMed: 34280647
  • DOI: 10.1016/j.psj.2021.101323

  14 Insights on

  • Reduced Inflammatory Response

  • Low evidence
  • Rigorous Journal
  • Animal Study

  L. acidophilus supplementation... decreased the serum CRP, DAO, and LPS levels at 14 d and 21 d; upregulated the mRNA expression of occludin and ZO-1 in the jejunum and ileum, and downregulated the mRNA expression of iNOS, IL-8, and IL-1β in the jejunum in E. coli challenged birds at 21 d (P < 0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• In Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression

  • 2021-02-23
  • mBio 12(1)
  • • Y. Goh
    • R. Barrangou
    • T. Klaenhammer

  • PubMed: 33500337
  • DOI: 10.1128/mBio.03399-20

  11 Insights on

  • Reduced Inflammatory Response

  • Low evidence

  Host colonization by L. acidophilus resulted in significant downregulation of several proinflammatory cytokines.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice.

  • 2020-02-11
  • Clinical Trial
  • Food & Function 10(9)
  • • Fenfen Yan
    • Na Li
    • Jialu Shi
    • Huizhen Li
    • Yingxue Yue
    • Wenshu Jiao
    • Nana Wang
    • Yue Song
    • G. Huo
    • Bailiang Li

  • PubMed: 31461095
  • DOI: 10.1039/c9fo01062a

  7 Insights on

  • Reduced Inflammatory Response

  • Low evidence
  • Highly Cited
  • Animal Study

  ...lowered inflammation cytokines, including IL-8, TNF-α and IL-1β in liver and colon tissue, and prevented liver and colon tissue injuries to some extent.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes