Lactobacillus acidophilus R0418 and Improved Gastrointestinal Health

• Effects of Lactobacillus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157

  • 2021-09
  • RCT · n = 360
  • Poultry Science 100(9)
  • • Zhengke Wu
    • Kexin Yang
    • A. Zhang
    • Wenhuan Chang
    • A. Zheng
    • Zhi-Min Chen
    • Huiyi Cai
    • Guohua Liu

  • PubMed: 34280647
  • DOI: 10.1016/j.psj.2021.101323

  14 Insights on

  • Improved Gastrointestinal Health

  • Low evidence
  • Rigorous Journal
  • Animal Study

  L. acidophilus supplementation reduced the mortality rate caused by E. coli challenge (P < 0.05), decreased the serum CRP, DAO, and LPS levels at 14 d and 21 d; upregulated the mRNA expression of occludin and ZO-1 in the jejunum and ileum, and downregulated the mRNA expression of iNOS, IL-8, and IL-1β in the jejunum in E. coli challenged birds at 21 d (P < 0.05).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes