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Evidence-Based Supplement Research
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Lactobacillus brevis SBC8803 and Improved Skin Hydration

Research synthesisLow evidenceMixed effect size10 studies · 10 beneficial · 0 neutral · 0 harmful

Across 10 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on skin hydration, with effects predominantly small to moderate in size. Only one study (a meta-analysis) reached statistical significance, while the primary RCT (n=126) showed marginal, non-significant improvements. Doses were not consistently reported, but one RCT used 25 mg/day and 50 mg/day of heat-killed SBC8803. Most studies were reviews, and the longest trials lasted 8–12 weeks.

  • Effective dose range: 25–50 mg/day
  • Studied populations: Adults with slightly elevated transepidermal water loss; healthy middle-aged women

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Most studies are reviews citing the same primary RCT, which itself reported marginal, non-significant findings; independent replication with larger samples is needed.

Generated May 12, 2026
10 of 10 papers
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