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Evidence-Based Supplement Research
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Lactobacillus brevis SBC8803 and Improved Skin Hydration

Research synthesisLow evidenceSmall effect10 studies · 10 beneficial · 0 neutral · 0 harmful

Across 10 studies, all reported beneficial effects on skin hydration from Lactobacillus brevis SBC8803, with predominantly small to moderate effect sizes. The strongest evidence comes from 2 randomized controlled trials (one with 126 adults and one with 60 women) showing marginal improvements in transepidermal water loss and corneal hydration, though only one study reached statistical significance. Doses and durations were not consistently reported, but the primary RCT used 25-50 mg/day for 8-12 weeks in adults with mild dry skin.

  • Effective dose range: 25-50 mg/day
  • Studied populations: adults with slightly elevated transepidermal water loss, healthy middle-aged Japanese women

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Most studies were reviews citing the same primary RCT, so the evidence base is narrower than the total count suggests.

Generated Jun 11, 2026
10 of 10 papers
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