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Evidence-Based Supplement Research
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Lactobacillus brevis SBC8803 and Improved Skin Hydration

Research synthesisLow evidenceSmall effect10 studies · 10 beneficial · 0 neutral · 0 harmful

Across 10 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on skin hydration, with predominantly small effect sizes. The most studied dose range is 25–50 mg/day (as heat-killed cells), and effects were observed in adults with slightly elevated transepidermal water loss, particularly middle-aged women. Only one study reached statistical significance, and the evidence base is heavily reliant on secondary reviews.

  • Effective dose range: 25–50 mg/day (heat-killed cells)
  • Studied populations: Adults with mild to moderate dry skin conditions, especially middle-aged women

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Only one primary randomized controlled trial (RCT) contributed marginal, non-significant findings; the rest are reviews citing the same or similar data. Doses and study durations were often unreported, and the form used (heat-killed postbiotic) may not generalize to live probiotic products.

Generated Jul 11, 2026
10 of 10 papers
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