Lactobacillus brevis SBC8803 and Reduced Inflammation

Research synthesisVery low evidenceModerate effect5 studies · 5 beneficial · 0 neutral · 0 harmful

Across 5 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on reduced inflammation, with the majority showing moderate effects. One randomized controlled trial in healthy adults found a statistically significant moderate effect on reducing exercise-induced inflammation. The evidence base is preliminary, consisting mostly of reviews and animal/mechanistic studies, with limited human data.

Studied populations: Healthy adults (from one RCT)

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 5 studies) — conclusions should be considered preliminary. Only 1 of 5 studies reported a statistically significant finding, and most studies were reviews or in vitro/in vivo work, not direct human trials on this specific strain.

Generated May 12, 2026

8 of 8 papers

Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans.
- 2022-11-03
- RCT
- Microorganisms 10(11)
- - Chia-Chia Lee
  - Yi-Chu Liao
  - Mon-Chien Lee
  - Yi-Chen Cheng
  - Shiou-Yun Chiou
  - Jin-Seng Lin
  - Chi-Chang Huang
  - Koichi Watanabe
- PubMed: 36363775
- DOI: 10.3390/microorganisms10112181
7 Insights on
- Reduced Inflammation
- High evidence
After six-week administration, both the TWK10 and TWK10-hk groups had significantly improved exercise performance and fatigue-associated features and reduced exercise-induced inflammation, compared with controls.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Postbiotics as Mitochondrial Modulators in Inflammatory Bowel Disease: Mechanistic Insights and Therapeutic Potential.
- 2025-07-01
- Review
- Biomolecules 15(7)
- - Santosh Kumar Prajapati
  - Dhananjay Yadav
  - Shweta Katiyar
  - Shalini Jain
  - Hariom Yadav
- PubMed: 40723826
- DOI: 10.3390/biom15070954
5 Insights on
- Reduced Inflammation
- Low evidence
Postbiotics have shown the ability to modulate mitochondrial health through multiple mechanisms... Collectively, this review explores the interplay between mitochondrial dysfunction, IBD, and preventive approach using postbiotics.
Effect
Beneficial
Effect size
Moderate
Emerging Links between Microbiome Composition and Skin Immunology in Diaper Dermatitis: A Narrative Review.
- 2022-01-15
- Review
- Children (Basel, Switzerland) 9(1)
- - Tjaša Hertiš Petek
  - Maya Petek
  - Tadej Petek
  - Nataša Marčun Varda
- PubMed: 35053737
- DOI: 10.3390/children9010112
4 Insights on
- Reduced Inflammation
- Low evidence
Probiotics are thought to work as a protective shield against irritants, maintain low skin pH, secrete beneficial metabolites, and block pathogen invasion.
Effect
Beneficial
Effect size
Small
Probiotic as a novel treatment strategy against liver disease.
- 2013-02-25
- Review
- Hepatitis monthly 13(2)
- - Abbas Ali Imani Fooladi
  - Hamideh Mahmoodzadeh Hosseini
  - Mohammad Reza Nourani
  - Soghra Khani
  - Seyed Moayed Alavian
- PubMed: 23610585
- DOI: 10.5812/hepatmon.7521
3 Insights on
- Reduced Inflammation
- Low evidence
decreases in compounds derived from bacteria, and lowers proinflammatory production such as TNF-α, IL-6 and IFN-γ via down-regulation of the nuclear factor kappa B (NF-κ B)
Effect
Beneficial
Effect size
Moderate
Probiotics and their beneficial effects on alcohol-induced liver injury in a rat model: the role of fecal microbiota.
- 2022-06-22
- BMC complementary medicine and therapies 22(1)
- - Maneerat Chayanupatkul
  - Kanjana Somanawat
  - Natthaya Chuaypen
  - Naruemon Klaikeaw
  - Natcha Wanpiyarat
  - Prasong Siriviriyakul
  - Somying Tumwasorn
  - Duangporn Werawatganon
- PubMed: 35733194
- DOI: 10.1186/s12906-022-03643-9
6 Insights on
- Reduced Inflammation
- Low evidence
- Animal Study
Significant elevation of serum ALT, LPS, IL-6, and TNF-α... were observed in alcohol-fed rats as compared with control rats. The administration of L. plantarum or mixed-strain probiotics restored these changes to the levels of control rats.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Inorganic polyphosphate from the immunobiotic Lactobacillus rhamnosus CRL1505 prevents inflammatory response in the respiratory tract
- 2021-10
- Clinical Trial
- Saudi Journal of Biological Sciences 28(10)
- - M. A. Correa Deza
  - A. Rodríguez de Olmos
  - N. Suárez
  - G. Font de Valdez
  - S. Salva
  - C. L. Gerez
- PubMed: 34588880
- DOI: 10.1016/j.sjbs.2021.06.010
3 Insights on
- Reduced Inflammation
- Low evidence
- Animal Study
the level of cytokines pro-inflammatory (IL-17, IL-6, IL-2, IL-4, INF-γ) in serum was normalized in mice treated with ICE, which would indicate that polyP prevents the local inflammatory response in the respiratory tract.
Effect
Beneficial
Effect size
Moderate
Oral administration of heat-inactivated Lactobacillus plantarum K37 modulated airway hyperresponsiveness in ovalbumin-sensitized BALB/c mice.
- 2014-06-17
- PloS one 9(6)
- - Yen-Wenn Liu
  - Tan-Wei Liao
  - Yu-Han Chen
  - Yi-Chin Chiang
  - Ying-Chieh Tsai
- PubMed: 24936861
- DOI: 10.1371/journal.pone.0100105
3 Insights on
- Reduced Inflammation
- Low evidence
- Animal Study
K37 also improved cell infiltration in lung sections. Our results demonstrated that oral administration of K37 alleviated effectively the allergic responses in vivo.
Effect
Beneficial
Effect size
Large
Lactobacillus paracasei CBA L74 metabolic products and fermented milk for infant formula have anti-inflammatory activity on dendritic cells in vitro and protective effects against colitis and an enteric pathogen in vivo.
- 2014-02-10
- PloS one 9(2)
- - Elena Zagato
  - Erika Mileti
  - Lucia Massimiliano
  - Francesca Fasano
  - Andrea Budelli
  - Giuseppe Penna
  - Maria Rescigno
- PubMed: 24520333
- DOI: 10.1371/journal.pone.0087615
3 Insights on
- Reduced Inflammation
- Low evidence
fermented products of Lactobacillus paracasei CBA L74 act via the inhibition of proinflammatory cytokine release leaving anti-inflammatory cytokines either unaffected or even increased
Effect
Beneficial
Effect size
Moderate