Lactobacillus plantarum DR7 and Reduced Pro-inflammatory Cytokine Levels

• Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study.

  • 2019-10
  • RCT · n = 103
  • Clinical Nutrition 38(5)
  • • L. Lew
    • Y. Hor
    • N. A. A. Yusoff
    • S. Choi
    • M. Yusoff
    • N. S. Roslan
    • Anisa Ahmad
    • J. A. Mohammad
    • M. F. I. L. Abdullah
    • Norzila Zakaria
    • N. Wahid
    • Zhihong Sun
    • L. Kwok
    • Heping Zhang
    • M. Liong

  • PubMed: 30266270
  • DOI: 10.1016/j.clnu.2018.09.010

  10 Insights on

  • Reduced Pro-inflammatory Cytokine Levels

  • High evidence
  • Highly Cited

  pro-inflammatory cytokines such as IFN-γ (mean difference 8.07 pg/ml; 95% CI -11.2 to -4.93; P < 0.001) and TNF-α (mean difference 1.52 pg/ml; 95% CI -2.14 to -0.89; P < 0.001) showed higher reduction as compared to placebo over 12-weeks.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.

  • 2020-12-02
  • Clinical Trial · n = 6
  • Beneficial Microbes 11(8)
  • • A. I. Zaydi
    • L. Lew
    • Y. Hor
    • M. Jaafar
    • L. Chuah
    • K. Yap
    • A. Azlan
    • G. Azzam
    • M. Liong

  • PubMed: 33245015
  • DOI: 10.3920/BM2019.0200

  3 Insights on

  • Reduced Pro-inflammatory Cytokine Levels

  • Low evidence
  • Animal Study

  Hippocampal concentration of all three pro-inflammatory cytokines were increased during aging but reduced upon administration of both statin and DR7.

  Effect

  Beneficial

  Effect size

  Moderate