Lactobacillus plantarum KABP-061 and Reduced Inflammation Levels

• Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder.

  • 2022-01-24
  • Clinical Trial
  • Journal of Agricultural and Food Chemistry 70(4)
  • • Lei Wang
    • Zijian Zhao
    • Lei Zhao
    • Yujuan Zhao
    • Ge Yang
    • Chao Wang
    • Lei Gao
    • Chunhua Niu
    • Shengyu Li

  • PubMed: 35067061
  • DOI: 10.1021/acs.jafc.1c07711

  16 Insights on

  • Reduced Inflammation Levels

  • Low evidence
  • Animal Study
  • Clinical

  L. plantarum DP189 increased the levels of... interleukin-10 (IL-10) and decreased the levels of... tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)...

  Effect

  Beneficial

  Effect size

  Moderate

• Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages.

  • 2014-07
  • Clinical Trial
  • International Immunopharmacology 21(1)
  • • Se-Eun Jang
    • M. Han
    • Se-Young Kim
    • Dong-Hyun Kim

  • PubMed: 24815859
  • DOI: 10.1016/j.intimp.2014.04.021

  3 Insights on

  • Reduced Inflammation Levels

  • Low evidence
  • Highly Cited
  • Animal Study

  Oral administration of CLP-0611 significantly reduced TNBS-induced body weight loss, colon shortening, myeloperoxidase activity, IRAK-1 phosphorylation, NF-κB and MAP kinase (p38, ERK, JNK) activation, and iNOS and COX-2 expression.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes