Lactobacillus reuteri MAK02L14R and Improved Intestinal Barrier Function

• Lactobacillus reuteri improves gut barrier function and affects diurnal variation of the gut microbiota in mice fed a high-fat diet.

  • 2020-01-15
  • Food & Function 10(8)
  • • Shuangqiu Li
    • Ce Qi
    • Hualing Zhu
    • R. Yu
    • C. Xie
    • Yuande Peng
    • S. Yin
    • Jianhui Fan
    • Suqing Zhao
    • Jin Sun

  • PubMed: 31304501
  • DOI: 10.1039/c9fo00417c

  17 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  Moreover, FN041 treatment improved intestinal epithelial barrier function

  Effect

  Beneficial

  Effect size

  Large

• Effects of Lactobacillus reuteri LR1 on the growth performance, intestinal morphology, and intestinal barrier function in weaned pigs.

  • 2018-04-12
  • RCT · n = 144
  • Journal of Animal Science 96(6)
  • • H. Yi
    • Li Wang
    • Yunxia Xiong
    • XiaoLu Wen
    • Zhilin Wang
    • Xuefen Yang
    • K. Gao
    • Zong-yong Jiang

  • PubMed: 29659876
  • DOI: 10.1093/jas/sky129

  6 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Rigorous Journal
  • Animal Study
  • Clinical

  LR1 increased (P < 0.05) tight junction protein zonula occludens-1 and occludin transcripts in the mucosa of the jejunum and ileum, and those of mucin-2 in ileal mucosa.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats.

  • 2018-02-16
  • Clinical Trial
  • Food & Function 7(5)
  • • Feng-Ching Hsieh
    • C. Lan
    • Tsui-Yin Huang
    • Kuan-Wei Chen
    • C. Chai
    • Wan-Tzu Chen
    • Ai-Hui Fang
    • Yi-Hsing Chen
    • Ching-Shuang Wu

  • PubMed: 27163114
  • DOI: 10.1039/c5fo01396h

  23 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study
  • Clinical

  The decreased intestinal barrier in the HFD group was markedly reversed by HK or live Lr263 treatments.

  Effect

  Beneficial

  Effect size

  Large