Reuterin Isolated from Lactobacillus reuteri Indonesian Strain Affected Interleukin-8 and Human Beta Defensin-2 on Pathogens Induced-HaCat Cells

2022-07-15
Tropical Life Sciences Research 33(2)
- A. Widyarman
- B. Bachtiar
- Endang Winiati Bahctiar

PubMed: 35966270
DOI: 10.21315/tlsr2022.33.2.5

Reduced Inflammation Levels

Low evidence

This study investigates the ability of reuterin isolated from L. reuteri Indonesian strain for increasing mRNA expression of interleukin (IL)-8 and human beta-defensin (hBD)-2 gene by epithelial cells, after exposure to oral bacteria... Quantitative PCR results showed reuterin decreased the expression of IL-8... Reuterin isolated from L. reuteri Indonesian strain increased expression of human beta defensin-2 as antimicrobial peptide and may be useful in combating inflammation.

Effect: Beneficial
Effect size: Moderate
Significant: Yes

Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats.

2018-02-16
Clinical Trial
Food & Function 7(5)
- Feng-Ching Hsieh
- C. Lan
- Tsui-Yin Huang
- Kuan-Wei Chen
- C. Chai
- Wan-Tzu Chen
- Ai-Hui Fang
- Yi-Hsing Chen
- Ching-Shuang Wu

PubMed: 27163114
DOI: 10.1039/c5fo01396h

24 Insights on

Reduced Inflammation Levels

Low evidence
Animal Study

The elevations of pro-inflammatory associated gene expressions in both adipose and hepatic tissues by high-fat administration were markedly decreased by HK or live Lr263 treatments.

Effect: Beneficial
Effect size: Large