Lactobacillus rhamnosus DSM33560 and Improved Intestinal Barrier Function

• Dietary Lactobacillus rhamnosus GG Supplementation Improves the Mucosal Barrier Function in the Intestine of Weaned Piglets Challenged by Porcine Rotavirus

  • 2016-01-04
  • RCT
  • PLOS ONE 11(1)
  • • X. Mao
    • Changsong Gu
    • Haiyan Hu
    • Jun Tang
    • Daiwen Chen
    • B. Yu
    • Jun He
    • Jie Yu
    • Junqiu Luo
    • G. Tian

  • PubMed: 26727003
  • DOI: 10.1371/journal.pone.0146312

  18 Insights on

  • Improved Intestinal Barrier Function

  • High evidence
  • Highly Cited
  • Rigorous Journal

  supplementing LGG in diets alleviated the diarrhea of weaned piglets challenged by RV via inhibiting the virus multiplication and improving the jejunal mucosal barrier function

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo.

  • 2009-06
  • Clinical Trial
  • Journal of Dairy Science 92(6)
  • • E. Miyauchi
    • H. Morita
    • S. Tanabe

  • PubMed: 19447972
  • DOI: 10.3168/jds.2008-1698

  8 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Highly Cited
  • Animal Study

  Oral treatment with both live and heat-killed OLL2838 suppressed weight loss and recovered colon length. Additionally, barrier function was restored by the administration of live and heat-killed OLL2838 to the DSS-treated animals, which conferred protection against the increase in mucosal permeability associated with DSS-induced colitis.

  Effect

  Beneficial

  Effect size

  Moderate