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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus rhamnosus GG and Reduced Abdominal Pain

Doses used in studies

CFU/day: 1 billion–6 billion (median 2.5 billion, IQR 1.3 billion–4.8 billion) — 2 studies

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

2 of 2 papers

Investigation of the Efficacy of Lactobacillus rhamnosus GG in Infants With Cow's Milk Protein Allergy: a Randomised Double-Blind Placebo-Controlled Trial.
- 2019-01-17
- RCT
- Probiotics and antimicrobial proteins 12(1)
- - Ahmet Basturk
  - İshak Isik
  - Atike Atalay
  - Aygen Yılmaz
- PubMed: 30656549
- DOI: 10.1007/s12602-019-9516-1
9 Insights on
- Reduced Abdominal Pain
- High evidence
- Rigorous Journal
- Clinical
no significant improvement were observed in abdominal pain (p = 0.325)
Effect
Neutral
Effect size
Small
Significant
No
Dose
1×10^9 CFU/day
Probiotics for paediatric functional abdominal pain disorders: A rapid review.
- 2019-05-04
- Review · n = 829
- Paediatrics & child health 24(6)
- - Fang Chao Linda Ding
  - Mohammad Karkhaneh
  - Liliane Zorzela
  - Hsing Jou
  - Sunita Vohra
- PubMed: 31528110
- DOI: 10.1093/pch/pxz036
1 Insight on
- Reduced Abdominal Pain
- High evidence
- Clinical
four (n=281) used Lactobacillus (L) reuteri DSM 17938, of which three (n=229) reported significant positive effects on either severity or frequency of pain
Effect
Beneficial
Effect size
Small
Significant
Yes