Lactobacillus rhamnosus GG and Reduced Diarrhea Rate

• Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults.

  • 2015-09-13
  • Meta-Analysis · n = 1,499
  • Alimentary pharmacology & therapeutics 42(10)
  • • H Szajewska
    • M Kołodziej

  • PubMed: 26365389
  • DOI: 10.1111/apt.13404

  1 Insight on

  • Reduced Diarrhea Rate

  • High evidence
  • Highly Cited
  • Rigorous Journal
  • Mixed

  Treatment with LGG compared with placebo or no additional treatment reduced the risk of AAD in patients treated with antibiotics from 22.4% to 12.3% (11 RCTs, n = 1308, relative risk, RR: 0.49, 95% confidence interval, CI: 0.29-0.83, low QoE).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Systematic review with meta-analysis: Lactobacillus rhamnosus GG for treating acute gastroenteritis in children - a 2019 update.

  • 2019-04-25
  • Meta-Analysis · n = 4,208
  • Alimentary pharmacology & therapeutics 49(11)
  • • Hania Szajewska
    • Maciej Kołodziej
    • Dorota Gieruszczak-Białek
    • Agata Skórka
    • Marek Ruszczyński
    • Raanan Shamir

  • PubMed: 31025399
  • DOI: 10.1111/apt.15267

  4 Insights on

  • Reduced Diarrhea Rate

  • High evidence
  • Rigorous Journal
  • Clinical

  L rhamnosus GG use ... was associated with a reduced duration of diarrhoea (15 RCTs, n = 3820, mean difference, MD -0.85 day, 95% CI -1.15 to -0.56)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes