Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus rhamnosus GG and Reduced Inflammation

Safety in these studies

Overall tolerabilityReported
While generally safe in healthy populations, rare adverse events (bacteremia, D-lactic acidosis, horizontal gene transfer) have been reported in immunocompromised or critically ill individuals, underscoring the need for individualized risk-benefit assessments and rigorous adverse-event surveillance.
from: Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Inte

2 of 2 papers

Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Intestinal, Neurologic, and Cardiovascular Health: a Narrative Review.
- 2026-11
- Review
- The Journal of nutritional biochemistry 157
- - Álvaro Vergara A Nieto
  - Andrés Halabi Diaz
  - Millaray Hernández Millán
  - Daniel Sagredo
  - Javier Arriagada Gacitua
- PubMed: 42177952
- DOI: 10.1016/j.jnutbio.2026.110424
10 Insights on
- Reduced Inflammation
- Low evidence
attenuate inflammation through cytokine modulation (↑IL-10, ↓TNF-α, IL-6)
Effect
Beneficial
Effect size
Small
Significant
Yes
Gut Microbiome Engineering for Diabetic Kidney Disease Prevention: A Lactobacillus rhamnosus GG Intervention Study.
- 2025-06-19
- Observational
- Biology 14(6)
- - Alaa Talal Qumsani
- PubMed: 40563973
- DOI: 10.3390/biology14060723
4 Insights on
- Reduced Inflammation
- Low evidence
Pro-inflammatory cytokine levels (IL-6, TNF-α) decreased significantly, while anti-inflammatory mediators (IL-10, TGF-β) exhibited enhanced expression.
Effect
Beneficial
Effect size
Moderate
Significant
Yes