Lactobacillus rhamnosus GR-1 and Reduced Inflammation

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all 3 reported beneficial moderate-sized effects of Lactobacillus rhamnosus GR-1 on reducing inflammation, with 2 of 3 findings reaching statistical significance. Evidence is derived from in vitro human cell line models, bovine cell studies, and a mouse model; no human clinical trials are included. Dose and form were not reported in any study.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All studies are preclinical (cell lines or animal models), so direct applicability to humans is uncertain. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). No dose or form data were reported, limiting practical guidance.

Generated May 12, 2026

4 of 4 papers

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses.
- 2019-03-18
- Scientific reports 9(1)
- - Bona Kim
  - Oksana Shynlova
  - Stephen Lye
- PubMed: 30886179
- DOI: 10.1038/s41598-019-41133-0
2 Insights on
- Reduced Inflammation
- Low evidence
- Rigorous Journal
L. rhamnosus GR-1 uniquely secretes heat-resistant but trypsin-sensitive factors, which significantly suppressed LPS-induced secretion of pro-inflammatory cytokines IL-6, IL-8, and MCP-1 in the human myometrial cell line, hTERT-HM.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota
- 2022-07-19
- Clinical Trial
- Frontiers in Nutrition 9
- - Xiaozhen Gu
  - Nanxi Bi
  - Tiandong Wang
  - Chengqing Huang
  - Rongrong Wang
  - Yi Xu
  - Hui-Li Wang
- PubMed: 35928850
- DOI: 10.3389/fnut.2022.934118
6 Insights on
- Reduced Inflammation
- Low evidence
- Animal Study
reduced proinflammatory cytokines [interleukin-1β (IL-1β) and IL-6] expression, and promoted anti-inflammatory cytokines [granulocyte colony-stimulating factor (G-CSF)] expression
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells
- 2022-03-02
- Frontiers in Cellular and Infection Microbiology 12
- - Jiawei Liu
  - Xiaowei Feng
  - Botong Li
  - Yan Sun
  - Tianxiong Jin
  - M. Feng
  - Yaodi Ni
  - Mingchao Liu
- PubMed: 35310848
- DOI: 10.3389/fcimb.2022.809674
2 Insights on
- Reduced Inflammation
- Low evidence
L. rhamnosus GR-1 could significantly alleviate the expression of E. coli-induced inflammatory factors... L. rhamnosus GR-1 can effectively protect against E. coli-induced inflammatory response
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.
- 2019-04-01
- European review for medical and pharmacological sciences 23(8)
- - Y Fang
  - H-Q Chen
  - X Zhang
  - H Zhang
  - J Xia
  - K Ding
  - Z-Y Fang
- PubMed: 31081110
- DOI: 10.26355/eurrev_201904_17722
3 Insights on
- Reduced Inflammation
- Low evidence
GR-1 attenuated the development of oxidative stress and chronic inflammation in a dose-dependent manner
Effect
Beneficial
Effect size
Moderate

Lactobacillus rhamnosus GR-1 and Reduced Inflammation

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses.

Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota

Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells

Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.