Lactobacillus rhamnosus GR-1 and Reduced Inflammation

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial moderate-sized effects of Lactobacillus rhamnosus GR-1 on reducing inflammation, with 2 of 3 findings statistically significant. Evidence is derived from in vitro, animal, and cell-based models, with no human clinical trials available. No consistent dose range or study duration was reported across studies.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All studies are preclinical (cell lines, animal models, or bovine cells), so relevance to human inflammation is uncertain.

Generated Jul 12, 2026

4 of 4 papersPopulation:

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses.
- 2019-03-18
- Scientific reports 9(1)
- - Bona Kim
  - Oksana Shynlova
  - Stephen Lye
- PubMed: 30886179
- DOI: 10.1038/s41598-019-41133-0
2 Insights on
- Reduced Inflammation
- Low evidence
- Rigorous Journal
L. rhamnosus GR-1 uniquely secretes heat-resistant but trypsin-sensitive factors, which significantly suppressed LPS-induced secretion of pro-inflammatory cytokines IL-6, IL-8, and MCP-1 in the human myometrial cell line, hTERT-HM.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota
- 2022-07-19
- Clinical Trial
- Frontiers in Nutrition 9
- - Xiaozhen Gu
  - Nanxi Bi
  - Tiandong Wang
  - Chengqing Huang
  - Rongrong Wang
  - Yi Xu
  - Hui-Li Wang
- PubMed: 35928850
- DOI: 10.3389/fnut.2022.934118
6 Insights on
- Reduced Inflammation
- Low evidence
- Animal Study
- Clinical
reduced proinflammatory cytokines [interleukin-1β (IL-1β) and IL-6] expression, and promoted anti-inflammatory cytokines [granulocyte colony-stimulating factor (G-CSF)] expression
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells
- 2022-03-02
- Frontiers in Cellular and Infection Microbiology 12
- - Jiawei Liu
  - Xiaowei Feng
  - Botong Li
  - Yan Sun
  - Tianxiong Jin
  - M. Feng
  - Yaodi Ni
  - Mingchao Liu
- PubMed: 35310848
- DOI: 10.3389/fcimb.2022.809674
2 Insights on
- Reduced Inflammation
- Low evidence
- Clinical
L. rhamnosus GR-1 could significantly alleviate the expression of E. coli-induced inflammatory factors... L. rhamnosus GR-1 can effectively protect against E. coli-induced inflammatory response
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.
- 2019-04-01
- European review for medical and pharmacological sciences 23(8)
- - Y Fang
  - H-Q Chen
  - X Zhang
  - H Zhang
  - J Xia
  - K Ding
  - Z-Y Fang
- PubMed: 31081110
- DOI: 10.26355/eurrev_201904_17722
3 Insights on
- Reduced Inflammation
- Low evidence
GR-1 attenuated the development of oxidative stress and chronic inflammation in a dose-dependent manner
Effect
Beneficial
Effect size
Moderate

Lactobacillus rhamnosus GR-1 and Reduced Inflammation

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses.

Probiotic Lactobacillus rhamnosus GR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota

Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells

Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.