Lactobacillus rhamnosus MAK79L08R and Improved Immunologic Barrier Function

• Dietary Lactobacillus rhamnosus GG Supplementation Improves the Mucosal Barrier Function in the Intestine of Weaned Piglets Challenged by Porcine Rotavirus

  • 2016-01-04
  • RCT
  • PLOS ONE 11(1)
  • • X. Mao
    • Changsong Gu
    • Haiyan Hu
    • Jun Tang
    • Daiwen Chen
    • B. Yu
    • Jun He
    • Jie Yu
    • Junqiu Luo
    • G. Tian

  • PubMed: 26727003
  • DOI: 10.1371/journal.pone.0146312

  18 Insights on

  • Improved Immunologic Barrier Function

  • High evidence
  • Highly Cited
  • Rigorous Journal

  Dietary LGG supplementation increased the villus height and villus height:crypt depth, the sIgA, IL-4, mucin 1 and mucin 2 concentrations, and the ZO-1, occludin and Bcl-2 mRNA levels of the jejunal mucosa (P<0.05)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets

  • 2019-02
  • RCT · n = 24
  • Journal of Zhejiang University-SCIENCE B 20(2)
  • • Yang Wang
    • L. Gong
    • Yan-ping Wu
    • Z. Cui
    • Yong-qiang Wang
    • Yi Huang
    • Xiao-ping Zhang
    • Wei-fen Li

  • PubMed: 30666850
  • DOI: 10.1631/jzus.B1800022

  14 Insights on

  • Improved Immunologic Barrier Function

  • Low evidence
  • Animal Study

  ...promoted the immunologic barrier through regulating antimicrobial peptides, cytokines, and chemokines via Toll-like receptors.

  Effect

  Beneficial

  Effect size

  Large