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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Lactobacillus rhamnosus and Improved Gut Microbiota Composition

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on gut microbiota composition, with effect sizes classified as moderate (2 studies) or small (1 study). The evidence base is small and preliminary, with no statistically significant findings reported and no consistent dose, duration, form, or population data available.

  • Studied populations: high-fat diet (HFD)-induced obese mice model (one animal study); human populations not specified in the available studies.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All reported effects are beneficial, but none of the studies reported statistical significance. Two of the three studies are narrative reviews, and the third is an animal study, limiting the strength of the evidence for human outcomes. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated May 12, 2026
4 of 4 papers
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