Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis.
- 2022-09-25
- Biomedicines 10(10)
- Laura-Dorina Dinu
- Ionela Avram
- Diana-Roxana Pelinescu
- Emanuel Vamanu
- PubMed: 36289654
- DOI: 10.3390/biomedicines10102392
Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. The current work comprehensively summarizes the benefits and potential applications of postbiotics and essential mineral-enriched biomass and proposes a new strategy for microbial therapy-mineral-enriched postbiotics. We hypothesize and critically review the relationship between micronutrients (calcium, magnesium, iron, zinc, selenium) and postbiotics with gut microbiota, which has been barely explored yet, and how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis. Additionally, the bioactive molecules and minerals from postbiotics could influence the host mineral status, directly or through gut microbiota, which increases the mineral bioavailability. The review increases our understanding of the health improvements of mineral-enriched postbiotics, including antioxidant functions, highlighting their perspective on microbial therapy to prevent and threaten gut-related diseases.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus rhamnosus lysate powder | Improved Bioavailability | Beneficial | Small |
| Lactobacillus rhamnosus lysate powder | Improved Gut Microbial Dysbiosis | Beneficial | Small |
| Lactobacillus rhamnosus lysate powder | Improved Gut Microbiota | Beneficial | Moderate |
| Lactobacillus rhamnosus lysate powder | Improved Gut Microbiota Composition | Beneficial | Moderate |
| Lactobacillus rhamnosus lysate powder | Increased Antioxidant Activity | Beneficial | Small |
| Lactobacillus rhamnosus lysate powder | Modulated Gut Microbiota | Beneficial | Small |