Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis.

2022-09-25
Biomedicines 10(10)
- Laura-Dorina Dinu
- Ionela Avram
- Diana-Roxana Pelinescu
- Emanuel Vamanu

PubMed: 36289654
DOI: 10.3390/biomedicines10102392

Study Design

Type: Review
Methods: The current work comprehensively summarizes the benefits and potential applications of postbiotics and essential mineral-enriched biomass and proposes a new strategy for microbial therapy-mineral-enriched postbiotics.

Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. The current work comprehensively summarizes the benefits and potential applications of postbiotics and essential mineral-enriched biomass and proposes a new strategy for microbial therapy-mineral-enriched postbiotics. We hypothesize and critically review the relationship between micronutrients (calcium, magnesium, iron, zinc, selenium) and postbiotics with gut microbiota, which has been barely explored yet, and how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis. Additionally, the bioactive molecules and minerals from postbiotics could influence the host mineral status, directly or through gut microbiota, which increases the mineral bioavailability. The review increases our understanding of the health improvements of mineral-enriched postbiotics, including antioxidant functions, highlighting their perspective on microbial therapy to prevent and threaten gut-related diseases.

Research Insights

Lactobacillus rhamnosus→Improved Bioavailability
the bioactive molecules and minerals from postbiotics could influence the host mineral status, directly or through gut microbiota, which increases the mineral bioavailability.
Effect
Beneficial
Effect size
Small
Lactobacillus rhamnosus→Improved Gut Microbial Dysbiosis
...the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis.
Effect
Beneficial
Effect size
Small
Lactobacillus rhamnosus→Improved Gut Microbiota
we hypothesize and critically review the relationship between micronutrients (calcium, magnesium, iron, zinc, selenium) and postbiotics with gut microbiota... how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus→Improved Gut Microbiota Composition
how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus→Increased Antioxidant Activity
The review increases our understanding of the health improvements of mineral-enriched postbiotics, including antioxidant functions...
Effect
Beneficial
Effect size
Small
Lactobacillus rhamnosus→Modulated Gut Microbiota
...how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis.
Effect
Beneficial
Effect size
Small