Lactobacillus salivarius SD-5208 and Improved Immune Response

• Assessment of Probiotic Properties of Lactobacillus salivarius Isolated From Chickens as Feed Additives

  • 2020-07-17
  • RCT
  • Frontiers in Veterinary Science 7
  • • Jian Wang
    • M. Ishfaq
    • Yuesheng Guo
    • Chunli Chen
    • Jichang Li

  • PubMed: 32766298
  • DOI: 10.3389/fvets.2020.00415

  12 Insights on

  • Improved Immune Response

  • Low evidence
  • Animal Study

  Lactobacillus salivarius results in enhanced immune response after IBDV vaccine immunization, enhanced specific antibody and IFN-γ production, and lymphocyte proliferation.

  Effect

  Beneficial

  Effect size

  Large

• Human-origin Lactobacillus salivarius AR809 protects against immunosuppression in S. aureus-induced pharyngitis via Akt-mediated NF-κB and autophagy signaling pathways.

  • 2020-10-07
  • Clinical Trial
  • Food & Function 11(1)
  • • G. Jia
    • Xiaofeng Liu
    • N. Che
    • Yongjun Xia
    • Guangqiang Wang
    • Z. Xiong
    • Hui Zhang
    • Lian-zhong Ai

  • PubMed: 31957758
  • DOI: 10.1039/c9fo02476j

  8 Insights on

  • Improved Immune Response

  • Low evidence
  • Animal Study

  AR809 significantly increased phagocytosis and bactericidal activity, reduced the production of inflammatory mediators (intracellular reactive oxygen species (ROS), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), nitric oxide (NO), inducible NOS (iNOS)) and the expression of inflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)), and induced macrophages to adopt the M2 phenotype.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition.

  • 2017-08-29
  • RCT · n = 10
  • Molecular Nutrition & Food Research 61(11)
  • • A. Rodríguez‐Nogales
    • F. Algieri
    • J. Garrido-Mesa
    • T. Vezza
    • M. P. Utrilla
    • N. Chueca
    • Federico García
    • M. Olivares
    • M. Rodríguez-Cabezas
    • J. Gálvez

  • PubMed: 28752563
  • DOI: 10.1002/mnfr.201700144

  12 Insights on

  • Improved Immune Response

  • Low evidence
  • Highly Cited
  • Animal Study

  Both probiotics ameliorated macroscopic colonic damage. They improved the colonic expression of markers involved in the immune response, and the expression of miR-155 and miR-223.

  Effect

  Beneficial

  Effect size

  Moderate