Lactobacillus salivarius SD-5208 and Reduced Inflammatory Response

• Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers

  • 2014-10-20
  • RCT · n = 45
  • Journal of Cardiovascular Pharmacology and Therapeutics 20(3)
  • • H. Rajkumar
    • Manoj Kumar
    • Nilita Das
    • Subramanian Hari Subbish Kumar
    • Hanumanth R. Challa
    • R. Nagpal

  • PubMed: 25331262
  • DOI: 10.1177/1074248414555004

  12 Insights on

  • Reduced Inflammatory Response

  • High evidence
  • Highly Cited

  Similarly, when compared to the placebo group, the serum concentrations of inflammatory markers such as high sensitivity C-reactive protein, interleukin (IL) 6, IL-1β, and tumor necrosis factor α were significantly (P < .05) reduced in both the experimental groups, but again the reduction in the synbiotic group was more pronounced.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Human-origin Lactobacillus salivarius AR809 protects against immunosuppression in S. aureus-induced pharyngitis via Akt-mediated NF-κB and autophagy signaling pathways.

  • 2020-10-07
  • Clinical Trial
  • Food & Function 11(1)
  • • G. Jia
    • Xiaofeng Liu
    • N. Che
    • Yongjun Xia
    • Guangqiang Wang
    • Z. Xiong
    • Hui Zhang
    • Lian-zhong Ai

  • PubMed: 31957758
  • DOI: 10.1039/c9fo02476j

  8 Insights on

  • Reduced Inflammatory Response

  • Low evidence
  • Animal Study

  AR809 also attenuated S. aureus-induced phosphorylations of protein kinase B (Akt) and rapamycin (mTOR), and elevated the autophagic protein (light chain 3 from II (LC3-II) and Beclin-1) level. Furthermore, AR809 inhibited nuclear transcription factor kappa-B (NF-κB) activation by suppressing the nuclear translocation of NF-κB p65.

  Effect

  Beneficial

  Effect size

  Large