Lactobacillus salivarius UALs07 and Reduced Inflammatory Response

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus salivarius on reducing inflammatory response, with effect sizes ranging from moderate to large. The strongest evidence comes from a randomized controlled trial showing significant reductions in inflammatory markers (hs-CRP, IL-6, IL-1β, TNF-α) in healthy young individuals, but the evidence base is very small and includes animal and genomic studies. No consistent dose range or form was reported across studies.

Studied populations: Healthy young individuals (one RCT), and H. pylori-infected gnotobiotic mice (one animal study)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Only one of the three studies was a human RCT with statistical significance; the remaining two are an animal model study and a genomic characterization study, which provide limited direct clinical evidence.

Generated May 12, 2026

3 of 3 papersPopulation:

Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers
- 2014-10-20
- RCT · n = 45
- Journal of Cardiovascular Pharmacology and Therapeutics 20(3)
- - H. Rajkumar
  - Manoj Kumar
  - Nilita Das
  - Subramanian Hari Subbish Kumar
  - Hanumanth R. Challa
  - R. Nagpal
- PubMed: 25331262
- DOI: 10.1177/1074248414555004
12 Insights on
- Reduced Inflammatory Response
- High evidence
- Highly Cited
- Adults
Similarly, when compared to the placebo group, the serum concentrations of inflammatory markers such as high sensitivity C-reactive protein, interleukin (IL) 6, IL-1β, and tumor necrosis factor α were significantly (P < .05) reduced in both the experimental groups, but again the reduction in the synbiotic group was more pronounced.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model
- 1998-11
- American Journal of Gastroenterology 93(11)
- - Y. Aiba
  - Nobuyuki Suzuki
  - A. M. Kabir
  - A. Takagi
  - Y. Koga
- PubMed: 9820379
- DOI: 10.1111/j.1572-0241.1998.00600.x
2 Insights on
- Reduced Inflammatory Response
- Low evidence
- Highly Cited
- Clinical
The validity of L. salivarius as a probiotic to suppress H. pylori and thus reduce the inflammatory response was again confirmed in vivo by using an H. pylori-infected gnotobiotic murine model.
Effect
Beneficial
Effect size
Large
Complete Genome Sequence of Lactobacillus salivarius CECT 5713, a Probiotic Strain Isolated from Human Milk and Infant Feces
- 2010-10
- Journal of Bacteriology 192(19)
- - E. Jiménez
  - Rocío Martín
  - Antonio Maldonado
  - V. Martín
  - Aranzazu Gómez de Segura
  - L. Fernández
  - J. M. Rodríguez
- PubMed: 20675488
- DOI: 10.1128/JB.00703-10
6 Insights on
- Reduced Inflammatory Response
- Low evidence
L. salivarius CECT 5713...has... anti-inflammatory... properties, as revealed by several in vitro and in vivo assays.
Effect
Beneficial
Effect size
Moderate

Lactobacillus salivarius UALs07 and Reduced Inflammatory Response

Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers

Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model

Complete Genome Sequence of Lactobacillus salivarius CECT 5713, a Probiotic Strain Isolated from Human Milk and Infant Feces