Lactococcus lactis VPro 34 and Enhanced Innate Immune Function

• Effects of Lactococcus lactis from Cyprinus carpio L. as probiotics on growth performance, innate immune response and disease resistance against Aeromonas hydrophila.

  • 2019-10
  • Clinical Trial
  • Fish & Shellfish Immunology 93
  • • Junchang Feng
    • Xulu Chang
    • Yuru Zhang
    • Xiao Yan
    • Jianxin Zhang
    • G. Nie

  • PubMed: 31302283
  • DOI: 10.1016/j.fsi.2019.07.028

  9 Insights on

  • Enhanced Innate Immune Function

  • Low evidence
  • Animal Study

  For the cytokines expression levels in serum, different expression patterns were also observed. Before the infection with Aeromonas hydrophila, L. lactis supplementation significant up-regulated protein levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-12) compared with negative (CK1) group, while these cytokines were significantly lower than those in positive (CK2) group after infection. However, whether infected or not, the expression of anti-inflammatory cytokines (IL-10, TGF-β) were significantly increased in L. lactis Q-8, L. lactis Q-9, and L. lactis Z-2 treatment groups.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Effects of Lactococcus lactis subsp. lactis I2 with β-Glucooligosaccharides on Growth, Innate Immunity and Streptococcosis Resistance in Olive Flounder (Paralichthys olivaceus).

  • 2018-09-28
  • RCT · n = 2
  • Journal of Microbiology and Biotechnology 28(9)
  • • M. T. Hasan
    • W. Jang
    • Jin Yeong Tak
    • Bong-Joo Lee
    • K. Kim
    • Sang-woo Hur
    • Hyonsob Han
    • Bo-Seong Kim
    • Do-Huh Min
    • Shin-Kwon Kim
    • I. Kong

  • PubMed: 30176713
  • DOI: 10.4014/jmb.1805.05011

  13 Insights on

  • Enhanced Innate Immune Function

  • Low evidence
  • Animal Study

  Results demonstrated the synbiotic diet had significantly better (*p* < 0.05) responses in terms of ... three innate immune parameters (respiratory burst, serum lysozyme, and superoxide dismutase).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Lactococcus lactis BFE920 activates the innate immune system of olive flounder (Paralichthys olivaceus), resulting in protection against Streptococcus iniae infection and enhancing feed efficiency and weight gain in large-scale field studies.

  • 2013-11
  • Clinical Trial · n = 12,000
  • Fish & Shellfish Immunology 35(5)
  • • Daniel Kim
    • B. Beck
    • Saet-Byeol Heo
    • Jungjoon Kim
    • Hyun Duk Kim
    • Sun-Min Lee
    • Youngchang Kim
    • So‐Young Oh
    • Kyung Yol Lee
    • H. Do
    • K. Lee
    • W. Holzapfel
    • S. Song

  • PubMed: 24041843
  • DOI: 10.1016/j.fsi.2013.09.008

  3 Insights on

  • Enhanced Innate Immune Function

  • Low evidence
  • Highly Cited
  • Animal Study

  This disease protection is due to the flounder's innate immunity activated by the L. lactis administration: increased lysosomal activities and production of IL-12 and IFN-γ.

  Effect

  Beneficial

  Effect size

  Moderate