Paecilomyces hepiali and Improved Immune Function

• Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

  • 2019-03-29
  • RCT · n = 79
  • BMC Complementary and Alternative Medicine 19(1)
  • • Su-Jin Jung
    • Eun-Soo Jung
    • Eun‐Kyung Choi
    • H. Sin
    • Ki-Chan Ha
    • S. Chae

  • PubMed: 30925876
  • DOI: 10.1186/s12906-019-2483-y

  4 Insights on

  • Improved Immune Function

  • High evidence
  • Rigorous Journal

  The CBG-CS-2 group showed a significant 38.8 ± 17.6% enhancement from the baseline of NK cell cytotoxic activity relative to the placebo group after the administration of the capsules for 8 wks. (P < 0.019).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Positive effects of extracellular polysaccharides from Paecilomyces hepiali on immune-enhancing properties by regulating gut microbiota in cyclophosphamide-induced mice.

  • 2024-08
  • International journal of biological macromolecules 274
  • • Baoming Tian
    • Yuezhi Jiang
    • Renjian Liu
    • Yahya S Hamed
    • Ahmed M Rayan
    • Shenlu Xu
    • Peilong Sun
    • Kai Yang

  • PubMed: 38917915
  • DOI: 10.1016/j.ijbiomac.2024.133390

  2 Insights on

  • Improved Immune Function

  • Low evidence
  • Animal Study

  PHP facilitated the secretion of serum cytokines, increased the mRNA and protein expression of TLR4/NF-κB signaling pathway. Furthermore, it improved the physical barrier function of the intestine by upregulating the expression of tight junction proteins.

  Effect

  Beneficial

  Effect size

  Moderate