Pediococcus pentosaceus KABP-041 and Improved Blood Lipid Metabolism

• Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish

  • 2023-02-01
  • Clinical Trial
  • Frontiers in Nutrition 10
  • • Yue Liu
    • D-L Zhu
    • Jiwen Liu
    • X. Sun
    • Feng Gao
    • Hui-Ping Duan
    • Lina Dong
    • Xin Wang
    • Changxing Wu

  • PubMed: 36819708
  • DOI: 10.3389/fnut.2023.1087703

  15 Insights on

  • Improved Blood Lipid Metabolism

  • Low evidence
  • Animal Study

  Probiotic exerted anti-adipogenic activity through regulating the expressions of SREBP1, FAS and LEPTIN. Levels of hepatic triglyceride, total cholesterol, low density lipoprotein were also reduced by probiotic.

  • Beneficial
  • Moderate effect

• Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice.

  • 2020-12-10
  • Clinical Trial
  • Journal of Agricultural and Food Chemistry 68(51)
  • • Yu Wang
    • Ying You
    • Yuan Tian
    • Haiyue Sun
    • Xia Li
    • Xiujuan Wang
    • Yuhua Wang
    • Jingsheng Liu

  • PubMed: 33300795
  • DOI: 10.1021/acs.jafc.0c05060

  10 Insights on

  • Improved Blood Lipid Metabolism

  • Low evidence
  • Animal Study

  The western blotting results suggested *P. pentosaceus* PP04 ameliorated high-fat diet-induced hyperlipidemia by the AMPK signaling pathway, which stimulated lipolysis via upregulation of PPARα and inhibited lipogenesis by downregulation of SREBP-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD1)...

  • Beneficial
  • Large effect